GRM5

Gene Symbol GRM5
Entrez Gene 2915
Alt Symbol GPRC1E, MGLUR5, PPP1R86, mGlu5
Species Human
Gene Type protein-coding
Description glutamate receptor, metabotropic 5
Other Description metabotropic glutamate receptor 5|protein phosphatase 1, regulatory subunit 86
Swissprots Q6J164 P41594
Accessions EAW59358 EAW59359 P41594 AF052171 AK291362 BAF84051 AW297388 AY608336 AAT37960 BC031602 BC047497 BX282658 CR627311 D28538 BAA05891 D28539 BAA05892 DA316590 DR002861 FJ588505 ACU31022 FJ588506 ACU31023 FJ588507 ACU31024 FJ668670 ACV89822 S64316 AAD13954 U79242 XM_006718828 XP_006718891 XM_011542792 XP_011541094 XM_011542793 XP_011541095 XM_011542794 XP_011541096 XM_011542795 XP_011541097 NM_000842 NP_000833 NM_001143831 NP_001137303
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}; Multi-pass membrane protein {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}.
Top Pathways Gap junction, Long-term potentiation, Huntington's disease, Calcium signaling pathway, Glutamatergic synapse

mGluR-5 (N-14) - sc-47147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
mGluR-5 (N-14): sc-47147. Immunoperoxidase staining of formalin fixed, paraffin-embedded human esophagus tissue showing nuclear and cytoplasmic staining of squamous epithelial cells.

Anti-Metabotropic Glutamate Receptor 5 antibody - ab27190 from Abcam

Prices $384.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Ab27190, at a dilution of 1/50, staining mGluR5 in Paraffin embedded formalin fixed human brain tissue section.

Anti-Metabotropic Glutamate Receptor 5 antibody - ab157689 from Abcam

Prices $376.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal
Immunohistochemical analysis of adult Mouse cochlear ganglion labeling Metabotropic Glutamate Receptor 5 with ab157689 at 1/200 dilution (green) and Neuron-specific class III beta-tubulin (red).

Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] - ab76316 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2425Y
ab76316 staining Metabotropic Glutmate Receptor 5 in mouse caudate putamen/ Corpus callosum by immunohistochemistry (frozen sections). Tissue was fixed with formaldehyde and samples were blocked with 1% BSA for 10 minutes at 21°C, before incubation with the primary antibody (1/2000) for 16 hours at 21°C. An alexa fluor® 594 conjugated goat anti-rabbit IgG secondary was used at 1/500.See Abreview

Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] (HRP) - ab196482 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2425Y
IHC image of Metabotropic Glutamate Receptor 5 staining in a section of formalin-fixed paraffin-embedded normal human cerebellum, performed on a Leica BOND. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab196482 at 1/100 dilution, for 15 mins at room temperature. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Metabotropic Glutamate Receptor 5 antibody [S75-33] - ab134271 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33
Overlay histogram showing SH-SH5Y cells stained with ab134271 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab134271, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Metabotropic Glutamate Receptor 5 antibody [S75-33] - C-terminal (Biotin) - ab183431 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-Metabotropic Glutamate Receptor 5 antibody [S75-33] - C-terminal (FITC) - ab183429 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-Metabotropic Glutamate Receptor 5 antibody [S75-33] - C-terminal (HRP) - ab183430 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-Metabotropic Glutamate Receptor 5b antibody - ab125261 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab125261 at 1/50 dilution, for 10 minutes at RT, staining Metabotropic Glutamate Receptor 5b in Formalin-Fixed Human brain tissue by Immunohistochemistry.

Anti-Metabotropic Glutamate Receptor 5b antibody - ab34520 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Metabotropic Glutamate Receptor 5b antibody - ab10311 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Metabotropic Glutamate Receptor 5b antibody - ab136864 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Metabotropic Glutamate Receptor 5b antibody (ab136864) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 390) - LS-C228676 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 488) - LS-C228677 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (C-Terminus) - LS-C211 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of HEK 293 cells expressing mGluR1a and mGluR5 showing the specific immunolabeling of the ~125k monomers and the ~250k dimers of mGluR1a and mGluR5.

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 565) - LS-C228678 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 655) - LS-C228679 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 633) - LS-C228680 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 594) - LS-C228681 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 680) - LS-C228682 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, AP) - LS-C228683 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (clone S75-33) - LS-C150480 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33
Western blot analysis of mGluR1-5 in rat brain membrane tissues, using a 1:1000 dilution of GRM1a / GRM5 antibody.

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, Atto 700) - LS-C228685 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33

Anti-GRM1a / GRM5 Antibody (aa824-1203, clone S75-33, APC) - LS-C228684 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S75-33
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