TRADD

Gene Symbol	TRADD
Entrez Gene	8717
Alt Symbol	Hs.89862
Species	Human
Gene Type	protein-coding
Description	TNFRSF1A-associated via death domain
Other Description	TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor type 1-associated DEATH domain protein|tumor necrosis factor receptor-1-associated protein
Swissprots	Q15628 B3KQZ9 Q52NZ1 B2RDS3
Accessions	AAS68637 AAX89407 CAC38018 CBW52910 EAW83081 Q15628 AK090673 BAG52211 AK301593 BAG63082 AK315654 BAG38020 BC004491 AAH04491 BG717460 BQ707739 BT006934 AAP35580 CA426418 DA353575 DQ893419 ABM84345 DQ896738 ABM87737 L41690 AAA98482 XM_005256213 XP_005256270 XM_011523420 XP_011521722 NM_003789 NP_003780 NM_153425
Function	The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11684708}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.
Tissue Specificity	Found in all examined tissues.
Top Pathways	Sphingolipid signaling pathway, Apoptosis, TNF signaling pathway, Epstein-Barr virus infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRADD (7G8) Rabbit mAb - 3684 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 7G8

TRADD Antibody - 3694 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

TRADD (A-5) - sc-46653 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TRADD (C-20) - sc-1163 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TRADD (H-278) - sc-7868 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab18914 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab170371 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab74320 from Abcam Prices $370.00 Sizes 1 ml Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab96552 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab58443 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab57789 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TRADD antibody - ab90132 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRADD antibody - ab155523 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRADD antibody [18A11] - ab49512 from Abcam Prices $359.00 Sizes 500 µl Host Mouse Clonality Monoclonal Clone 18A11

Anti-TRADD antibody [EPR3604] - ab110644 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3604

Anti-TRADD antibody, prediluted - ab15567 from Abcam Prices $370.00 Sizes 7 ml Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (C-Terminus) - LS-C10917 from LifeSpan Bioscience Prices $455.00 Sizes 500 µl Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (C-Terminus, Azide-free) - LS-C10918 from LifeSpan Bioscience Prices $475.00 Sizes 500 µl Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (PE) - LS-C40024 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-TRADD Antibody (aa172-192) - LS-C148293 from LifeSpan Bioscience Prices $335.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (C-Terminus) - LS-C50696 from LifeSpan Bioscience Prices $440.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (C-Terminus) - LS-C189267 from LifeSpan Bioscience Prices $425.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (clone 3G1) - LS-C139379 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G1

Anti-TRADD Antibody (Internal) - LS-C209829 from LifeSpan Bioscience Prices $405.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-TRADD Antibody (C-Terminus) - LS-C112279 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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