TRADD

Gene Symbol	TRADD
Entrez Gene	8717
Alt Symbol	Hs.89862
Species	Human
Gene Type	protein-coding
Description	TNFRSF1A-associated via death domain
Other Description	TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor type 1-associated DEATH domain protein|tumor necrosis factor receptor-1-associated protein
Swissprots	Q15628 B3KQZ9 Q52NZ1 B2RDS3
Accessions	AAS68637 AAX89407 CAC38018 CBW52910 EAW83081 Q15628 AK090673 BAG52211 AK301593 BAG63082 AK315654 BAG38020 BC004491 AAH04491 BG717460 BQ707739 BT006934 AAP35580 CA426418 DA353575 DQ893419 ABM84345 DQ896738 ABM87737 L41690 AAA98482 XM_005256213 XP_005256270 XM_011523420 XP_011521722 NM_003789 NP_003780 NM_153425
Function	The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11684708}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.
Tissue Specificity	Found in all examined tissues.
Top Pathways	Sphingolipid signaling pathway, Apoptosis, TNF signaling pathway, Epstein-Barr virus infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRADD Antibody Blocking Peptide - LS-E1332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRADD Antibody Blocking Peptide - LS-E10542 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRADD Protein - H00008717-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human TRADD Protein - H00008717-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRADD-Antibody-Center-Blocking-peptide - BP11963c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

soluble TNF Receptor I protein - GTX29980 from GeneTex Category Protein Prices $269.00 Sizes 20 μg Source E. coli Species Human

TRADD peptide - orb73292 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

TRADD Blocking Peptide - 33R-10804 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

TRADD Blocking Peptide - 33R-10088 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human TRADD Protein - abx069351 from Abbexa Category Protein Source E.coli Species Human

TRADD - H00008717-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

TRADD - H00008717-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRADD - H00008717-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRADD control peptide - AP00240CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Recombinant Human TRADD - 230-00667-10 from RayBiotech Category Protein Prices $86.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human TRADD - 230-00667-50 from RayBiotech Category Protein Prices $174.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human TRADD - 230-00667-100 from RayBiotech Category Protein Prices $261.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human TRADD - 230-00667-200 from RayBiotech Category Protein Prices $469.00 Sizes 200 µg Source Escherichia coli (E.coli) Species Human

TNFRSF1A Associated Via Death Domain Protein - 20-9528 from ARP American Research Products Category Protein Prices $481.00 Sizes 50 µg Source E.coli Species Human

TRADD fusion protein - Ag7768 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human TRADD, His-tagged - TRADD-29977TH from Creative Biomart Category Protein Source E. coli

Recombinant Human TRADD, His-tagged - TRADD-3383H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant TNFRSF1A Associated Via Death Domain Protein (TRADD) - RPM390Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant TNFRSF1A Associated Via Death Domain Protein (TRADD) - RPM390Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant TNFRSF1A Associated Via Death Domain Protein (TRADD) - RPM390Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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