| Gene Symbol |
TRADD
|
| Entrez Gene |
8717
|
| Alt Symbol |
Hs.89862
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNFRSF1A-associated via death domain
|
| Other Description |
TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor type 1-associated DEATH domain protein|tumor necrosis factor receptor-1-associated protein
|
| Swissprots |
Q15628 B3KQZ9 Q52NZ1 B2RDS3
|
| Accessions |
AAS68637 AAX89407 CAC38018 CBW52910 EAW83081 Q15628 AK090673 BAG52211 AK301593 BAG63082 AK315654 BAG38020 BC004491 AAH04491 BG717460 BQ707739 BT006934 AAP35580 CA426418 DA353575 DQ893419 ABM84345 DQ896738 ABM87737 L41690 AAA98482 XM_005256213 XP_005256270 XM_011523420 XP_011521722 NM_003789 NP_003780 NM_153425
|
| Function |
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11684708}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Found in all examined tissues.
|
| Top Pathways |
Sphingolipid signaling pathway, Apoptosis, TNF signaling pathway, Epstein-Barr virus infection, Viral carcinogenesis
|