TRADD
| Gene Symbol | TRADD |
|---|---|
| Entrez Gene | 8717 |
| Alt Symbol | Hs.89862 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TNFRSF1A-associated via death domain |
| Other Description | TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor type 1-associated DEATH domain protein|tumor necrosis factor receptor-1-associated protein |
| Swissprots | Q15628 B3KQZ9 Q52NZ1 B2RDS3 |
| Accessions | AAS68637 AAX89407 CAC38018 CBW52910 EAW83081 Q15628 AK090673 BAG52211 AK301593 BAG63082 AK315654 BAG38020 BC004491 AAH04491 BG717460 BQ707739 BT006934 AAP35580 CA426418 DA353575 DQ893419 ABM84345 DQ896738 ABM87737 L41690 AAA98482 XM_005256213 XP_005256270 XM_011523420 XP_011521722 NM_003789 NP_003780 NM_153425 |
| Function | The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11684708}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}. |
| Tissue Specificity | Found in all examined tissues. |
| Top Pathways | Sphingolipid signaling pathway, Apoptosis, TNF signaling pathway, Epstein-Barr virus infection, Viral carcinogenesis |
TRADD CRISPR/Cas9 KO Plasmid (h) - sc-401177 from Santa Cruz Biotechnology
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TRADD HDR Plasmid (h) - sc-401177-HDR from Santa Cruz Biotechnology
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TRADD Double Nickase Plasmid (h) - sc-401177-NIC from Santa Cruz Biotechnology
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TRADD Double Nickase Plasmid (h2) - sc-401177-NIC-2 from Santa Cruz Biotechnology
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TRADD CRISPR Activation Plasmid (h) - sc-401177-ACT from Santa Cruz Biotechnology
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TRADD CRISPR Activation Plasmid (h2) - sc-401177-ACT-2 from Santa Cruz Biotechnology
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TRADD Lentiviral Activation Particles (h) - sc-401177-LAC from Santa Cruz Biotechnology
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TRADD Lentiviral Activation Particles (h2) - sc-401177-LAC-2 from Santa Cruz Biotechnology
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TRADD siRNA (h) - sc-36709 from Santa Cruz Biotechnology
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TRADD shRNA Plasmid (h) - sc-36709-SH from Santa Cruz Biotechnology
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TRADD shRNA (h) Lentiviral Particles - sc-36709-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21902 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21902 from Sigma-Aldrich
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TRADD siRNA (Human) - CRH5738 from Cohesion Biosciences
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TRADD RNAi - H00008717-R01 from Novus Biologicals
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TRADD - MBS8234772 from MyBioSource
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shRNA set against Human TRADD (NM_003789.3) - SHH433668 from Creative biogene
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shRNA set against Human TRADD(NM_003789.3) - SHL085026 from Creative biogene
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Human TRADD siRNA - orb266240 from Biorbyt
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TRADD shRNA Plasmid (Human) - CHH5738 from Cohesion Biosciences
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TRADD miRNA 3'UTR clone - MiUTR1H-10695 from Creative biogene
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