MMP13

Gene Symbol	MMP13
Entrez Gene	4322
Alt Symbol	CLG3, MANDP1, MMP-13
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 13
Other Description	collagenase 3|matrix metallopeptidase 13 (collagenase 3)|matrix metalloproteinase 13 (collagenase 3)
Swissprots	P45452 B2RCZ3 A8K846 Q6NWN6
Accessions	AAU13907 CAA57296 CCO13773 CCQ43178 EAW67034 EAW67035 P45452 AK222748 BAD96468 AK292211 BAF84900 AK315341 BAG37740 AY256443 AAP78939 AY256444 AAP78940 BC067522 AAH67522 BC067523 AAH67523 BC074807 AAH74807 BC074808 AAH74808 CA413743 HQ258010 ADR82764 X75308 CAA53056 X81334 CAA57108 NM_002427 NP_002418
Function	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:00
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}.
Tissue Specificity	Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8798568, ECO:0000269|PubMed:9056642, ECO:0000269|PubMed:9562863}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MMP13 Human ELISA Kit - ab100605 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 6 pg/ml Range 8.23 pg/ml - 6000 pg/ml

Rat MMP13 ELISA Kit (Sandwich ELISA) - LS-F5518 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.064 ng/ml Range 0.156-10 ng/ml

Mouse MMP13 ELISA Kit (Sandwich ELISA) - LS-F5519 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 15.6 pg/ml Range 0.156-10 ng/ml

Rabbit MMP13 ELISA Kit (Sandwich ELISA) - LS-F5900 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human MMP13 ELISA Kit (Sandwich ELISA) - LS-F2520 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 5 pg/ml Range 0.156-10 ng/ml

Human MMP13 ELISA Kit (Sandwich ELISA) - LS-F4962 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.113 ng/ml Range 0.156-10 ng/ml

Horse MMP13 ELISA Kit (Sandwich ELISA) - LS-F6170 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.29 ng/ml Range 0.156-10 ng/ml

Goat MMP13 ELISA Kit (Sandwich ELISA) - LS-F6169 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 1.26 ng/ml Range 0.156-10 ng/ml

Pig MMP13 ELISA Kit (Sandwich ELISA) - LS-F6172 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 62.5 pg/ml Range 0.156-10 ng/ml

Chicken MMP13 ELISA Kit (Sandwich ELISA) - LS-F6171 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 5.7 ng/ml Range 0.156-10 ng/ml

Bovine MMP13 ELISA Kit (Sandwich ELISA) - LS-F6168 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.59 ng/ml Range 0.156-10 ng/ml

Human MMP13 ELISA Kit (Sandwich ELISA) - LS-F156 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 8.23 pg/ml Range 0.156-10 ng/ml

Human MMP13 ELISA Kit (Cell-Based ELISA) - LS-F2156 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse MMP13 ELISA Kit (Sandwich ELISA) - LS-F12053 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human MMP13 ELISA Kit (Sandwich ELISA) - LS-F12054 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human MMP-13 ELISA Kit - RAB0364 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

Human MMP-13 Luminex Performance Assay - LMP511B from R&D Systems Prices $179.00 Sizes 1 kit

Human MMP-13 Magnetic Luminex Performance Assay - LMPM511 from R&D Systems

Human Pro-MMP-13 Quantikine ELISA Kit - DM1300 from R&D Systems Category ELISA Kit Prices $479.00, $2,290.00, $15,560.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 21.3 pg/mL Range 78.0 - 5,000 pg/mL (Cell Culture Supernates)

Human Pro-MMP-13 Quantikine PharmPak (50 Plates) - PDM1300 from R&D Systems Category ELISA Kit Sensitivity 21.3 pg/mL Range 78 - 5,000 pg/mL (Cell Culture Supernates)

Human Pro-MMP-13 Quantikine SixPak (6 Plates) - SMP1300 from R&D Systems Category ELISA Kit Sensitivity 21.3 pg/mL Range 78 - 5,000 pg/mL (Cell Culture Supernates)

Human Pro-MMP-13 DuoSet ELISA - DY913 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Quantikine Immunoassay Control Set 837 for Human Pro-MMP-13 - QC132 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human Total MMP-13 DuoSet ELISA - DY511 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human Active MMP-13 Fluorokine E Kit - F13M00 from R&D Systems Prices $479.00 Sizes 1 kit

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