MMP13

Gene Symbol	MMP13
Entrez Gene	4322
Alt Symbol	CLG3, MANDP1, MMP-13
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 13
Other Description	collagenase 3\|matrix metallopeptidase 13 (collagenase 3)\|matrix metalloproteinase 13 (collagenase 3)
Swissprots	P45452 B2RCZ3 A8K846 Q6NWN6
Accessions	AAU13907 CAA57296 CCO13773 CCQ43178 EAW67034 EAW67035 P45452 AK222748 BAD96468 AK292211 BAF84900 AK315341 BAG37740 AY256443 AAP78939 AY256444 AAP78940 BC067522 AAH67522 BC067523 AAH67523 BC074807 AAH74807 BC074808 AAH74808 CA413743 HQ258010 ADR82764 X75308 CAA53056 X81334 CAA57108 NM_002427 NP_002418
Function	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269\|PubMed:16167086, ECO:0000269\|PubMed:17623656, ECO:00
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000305\|PubMed:8576151}. Secreted {ECO:0000269\|PubMed:8576151}.
Tissue Specificity	Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269\|PubMed:8207000, ECO:0000269\|PubMed:8798568, ECO:0000269\|PubMed:9056642, ECO:0000269\|PubMed:9562863}.

MMP-13 (H-230) - sc-30073 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

MMP-13 (H-230): sc-30073. Western blot analysis of human recombinant MMP-13.

MMP-13 (D-17) - sc-12363 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MMP-13 (D-17): sc-12363. Western blot analysis of human recombinant MMP-13.

MMP-13 (T-14) - sc-31813 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MMP-13 (W-16) - sc-31811 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MMP-13 (MM0019-12E10) - sc-101564 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

Anti-MMP13 antibody - ab75606 from Abcam

Prices	$382.00
Sizes	250 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MMP13 antibody (ab75606) at 5 µg/ml + Conditioned, serum-free medium from (TPA-treated) rat CCL-4 cells

Anti-MMP13 antibody - ab84594 from Abcam

Prices	$382.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MMP13 antibody (ab84594) at 1 µg/mlLane 1 : MDA-MB-231 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 2 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MMP13 antibody - ab9128 from Abcam

Prices	$359.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MMP13 antibody - ab53711 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MMP13 antibody (ab53711) at 1/500 dilutionLane 1 : Extracts from LOVO cells, minus immunising peptideLane 2 : Extracts from LOVO cells, plus immunising peptide

Anti-MMP13 antibody - ab39023 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MMP13 antibody (ab39023) at 1/3000 dilutionLane 1 : Cell media from human chondrosarcoma (not treated) Lane 2 : Cell media from human chondrosarcoma (treated with IL1 beta) Lane 3 : Cell media from human chondrosarcoma (treated with TNF alpha)

Anti-MMP13 antibody [EP1263Y] - ab51072 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP1263Y

Anti-MMP13 antibody [EP1263Y] (ab51072) at 1/500 dilution + HeLa cell lysate at 10 µgSecondaryGoat anti-Rabbit HRP labeled at 1/2000 dilution

Anti-MMP13 antibody [M33] - ab1010 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Mouse
Clonality	Monoclonal
Clone	M33

Anti-MMP13 antibody [SPM291], prediluted - ab54308 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	SPM291

Ab54308 staining human MMP13 in human placenta tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-MMP13 antibody [VIIIA2] - ab3208 from Abcam

Prices	$379.00
Sizes	500 µl
Host	Mouse
Clonality	Monoclonal
Clone	VIIIA2

ICC/IF image of ab3208 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab3208, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MMP13 antibody - Aminoterminal end - ab39016 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MMP13 antibody - Aminoterminal end (ab39016) at 1/3000 dilutionLane 1 : cell media from human chondrosarcoma (untreated)Lane 2 : cell media from human chondrosarcoma (IL1 beta treated)

Anti-MMP13 antibody - Carboxyterminal end - ab39021 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MMP13 antibody - Carboxyterminal end (ab39021) at 1/3000 dilutionLane 1 : Cell media from human chondrosarcoma (no treatment)Lane 2 : Cell media from human chondrosarcoma. (treated with IL1 beta).

Anti-MMP13 Antibody (aa310-324) - LS-C3112 from LifeSpan Bioscience

Prices	$285.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MMP13 Antibody - LS-C8852 from LifeSpan Bioscience

Prices	$455.00
Sizes	500 µl
Host	Mouse
Clonality	Monoclonal

Anti-MMP13 Antibody (aa104-471, clone 3H3) - LS-C338153 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3H3

IHC of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-MMP13 Antibody (aa104-471, clone 2D8) - LS-C338200 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2D8

IHC of paraffin-embedded Human liver tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-MMP13 Antibody - LS-C8864 from LifeSpan Bioscience

Prices	$515.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-MMP13 Antibody - LS-C8863 from LifeSpan Bioscience

Prices	$495.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-MMP13 Antibody - LS-C8867 from LifeSpan Bioscience

Prices	$355.00
Sizes	250 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MMP13 Antibody - LS-C11394 from LifeSpan Bioscience

Prices	$485.00
Sizes	1 ml
Host	Sheep
Clonality	Polyclonal

Anti-MMP13 Antibody (clone SPM292) - LS-C32757 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	SPM292

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