MMP13

Gene Symbol	MMP13
Entrez Gene	4322
Alt Symbol	CLG3, MANDP1, MMP-13
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 13
Other Description	collagenase 3|matrix metallopeptidase 13 (collagenase 3)|matrix metalloproteinase 13 (collagenase 3)
Swissprots	P45452 B2RCZ3 A8K846 Q6NWN6
Accessions	AAU13907 CAA57296 CCO13773 CCQ43178 EAW67034 EAW67035 P45452 AK222748 BAD96468 AK292211 BAF84900 AK315341 BAG37740 AY256443 AAP78939 AY256444 AAP78940 BC067522 AAH67522 BC067523 AAH67523 BC074807 AAH74807 BC074808 AAH74808 CA413743 HQ258010 ADR82764 X75308 CAA53056 X81334 CAA57108 NM_002427 NP_002418
Function	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:00
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}.
Tissue Specificity	Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8798568, ECO:0000269|PubMed:9056642, ECO:0000269|PubMed:9562863}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLG3 Gene - orb92920 from Biorbyt Prices $306.00 Sizes 10 μg Species Human

MMP13 - MBS1270816 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC067522

Human MMP-13 Gene ORF cDNA clone in cloning vector - HG12088-G from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12088-CM from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12088-CY from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid - HG12088-UT from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12088-NY from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, N-His tag - HG12088-NH from Sino Biological Species Human

Human MMP13 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG12088-G-F from Sino Biological Species Human Accession NM_002427

Human MMP-13 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12088-NF from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12088-ACR from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, C-His tag - HG12088-CH from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12088-NM from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12088-CF from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12088-ACG from Sino Biological Species Human

Human MMP-13 Gene ORF cDNA clone expression plasmid - HG11852-G-N from Sino Biological Species Human

Human MMP13 ORF Clone (BC067522) - CDCS410786 from Creative biogene Species Human Accession P45452

Human MMP13 ORF clone (NM_002427) - CDCB160262 from Creative biogene Species Human

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