MMP13

Gene Symbol	MMP13
Entrez Gene	4322
Alt Symbol	CLG3, MANDP1, MMP-13
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 13
Other Description	collagenase 3|matrix metallopeptidase 13 (collagenase 3)|matrix metalloproteinase 13 (collagenase 3)
Swissprots	P45452 B2RCZ3 A8K846 Q6NWN6
Accessions	AAU13907 CAA57296 CCO13773 CCQ43178 EAW67034 EAW67035 P45452 AK222748 BAD96468 AK292211 BAF84900 AK315341 BAG37740 AY256443 AAP78939 AY256444 AAP78940 BC067522 AAH67522 BC067523 AAH67523 BC074807 AAH74807 BC074808 AAH74808 CA413743 HQ258010 ADR82764 X75308 CAA53056 X81334 CAA57108 NM_002427 NP_002418
Function	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:00
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}.
Tissue Specificity	Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8798568, ECO:0000269|PubMed:9056642, ECO:0000269|PubMed:9562863}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MMP-13 CRISPR/Cas9 KO Plasmid (h) - sc-400626 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 HDR Plasmid (h) - sc-400626-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 Double Nickase Plasmid (h) - sc-400626-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 Double Nickase Plasmid (h2) - sc-400626-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 CRISPR Activation Plasmid (h) - sc-400626-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 CRISPR Activation Plasmid (h2) - sc-400626-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 Lentiviral Activation Particles (h) - sc-400626-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 Lentiviral Activation Particles (h2) - sc-400626-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MMP-13 siRNA (h) - sc-41559 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MMP-13 shRNA Plasmid (h) - sc-41559-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MMP-13 shRNA (h) Lentiviral Particles - sc-41559-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MMP-13 RNAi - H00004322-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MMP-13 RNAi - H00004322-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU067151 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2083 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2083 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08799 from Sigma-Aldrich Category miRNA

MMP13 siRNA (Human) - CRH2934 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MMP13 (NM_002427.3) - SHH342900 from Creative biogene Category siRNA Species Reactivities Human

Human MMP13 siRNA - orb263436 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MMP13 shRNA Plasmid (Human) - CHH2934 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MMP13 miRNA 3'UTR clone - MiUTR3H-03138 from Creative biogene Species Reactivities Human

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