MMP13

Gene Symbol	MMP13
Entrez Gene	4322
Alt Symbol	CLG3, MANDP1, MMP-13
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 13
Other Description	collagenase 3|matrix metallopeptidase 13 (collagenase 3)|matrix metalloproteinase 13 (collagenase 3)
Swissprots	P45452 B2RCZ3 A8K846 Q6NWN6
Accessions	AAU13907 CAA57296 CCO13773 CCQ43178 EAW67034 EAW67035 P45452 AK222748 BAD96468 AK292211 BAF84900 AK315341 BAG37740 AY256443 AAP78939 AY256444 AAP78940 BC067522 AAH67522 BC067523 AAH67523 BC074807 AAH74807 BC074808 AAH74808 CA413743 HQ258010 ADR82764 X75308 CAA53056 X81334 CAA57108 NM_002427 NP_002418
Function	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:00
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}.
Tissue Specificity	Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8798568, ECO:0000269|PubMed:9056642, ECO:0000269|PubMed:9562863}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MMP13 protein fragment - ab134452 from Abcam Category Protein Prices $665.00 Sizes 50 µl Source E. coli Species Human

Human MMP13 full length protein - ab177626 from Abcam Category Protein Source E. coli Species Human

Human MMP13 full length protein - ab185608 from Abcam Category Protein Source E. coli Species Human

Human MMP13 peptide - ab93499 from Abcam Category Peptide

MMP13 peptide - ab44853 from Abcam Category Peptide

MMP13 peptide - ab44855 from Abcam Category Peptide

MMP13 peptide - ab45252 from Abcam Category Peptide

MMP13 Antibody Blocking Peptide - LS-E2636 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MMP13 Antibody Blocking Peptide - LS-E20443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MMP13 Antibody Blocking Peptide - LS-E8124 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MMP13 Antibody Blocking Peptide - LS-E28323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MMP13 Antibody Blocking Peptide - LS-E28324 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MMP13 Antibody Blocking Peptide - LS-E28325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MMP13 Antibody Blocking Peptide - LS-E28326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MMP-13 Partial Recombinant Protein - H00004322-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MMP-13 Recombinant Protein - P4925 from Novus Biologicals Category Protein Prices $1,049.00 Sizes 10 µg Species Human

MMP-13 Recombinant Protein - P4924 from Novus Biologicals Category Protein Prices $1,049.00 Sizes 10 µg Species Human

Recombinant Human MMP-13 Protein - NBP1-99622 from Novus Biologicals Category Protein Prices $345.00 Sizes 10 µg Source Sf9 cells Species Human

MMP-13 Peptide - P1805 from Novus Biologicals Category Peptide Species Human

MMP13-Antibody-Center-Blocking-peptide - BP13706c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MMP13-Antibody-C-term-Blocking-Peptide - BP6197a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human MMP-13, CF - 511-MM-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu20-Cys471

Recombinant Human MMP-13 Western Blot Standard Protein - WBC020 from R&D Systems Category Protein Prices $109.00 Sizes 1 vial Species Human

MMP 13 Protein (OPPA00837) - OPPA00837 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human MMP13 protein - orb246393 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

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