IL23A

Gene Symbol IL23A
Entrez Gene 51561
Alt Symbol IL-23, IL-23A, IL23P19, P19, SGRF
Species Human
Gene Type protein-coding
Description interleukin 23, alpha subunit p19
Other Description IL-23 subunit alpha|IL-23-A|IL-23p19|JKA3 induced upon T-cell activation|interleukin 23 p19 subunit|interleukin-23 subunit alpha|interleukin-23 subunit p19|interleukin-six, G-CSF related factor
Swissprots Q9H2A5 Q6NZ82 Q6NZ80 Q9NPF7
Accessions BAA93687 CAM82731 CBX47553 CCA63964 EAW96933 Q9NPF7 AB030000 BAA93686 AF301620 AAG37232 AJ506993 CAD45088 AY359083 AAQ89442 BC066267 AAH66267 BC066268 AAH66268 BC066269 AAH66269 BC067511 AAH67511 BC067512 AAH67512 BC067513 AAH67513 BM842783 BM851337 HQ447589 ADQ32075 U38443 XM_011538477 XP_011536779 NM_016584 NP_057668
Function Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}.
Subcellular Location Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
Tissue Specificity Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Rheumatoid arthritis, Pertussis, Tuberculosis

IL-23 (C-3) - sc-271279 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-23 (C-3): sc-271279. Western blot analysis of IL-23 expression in non-transfected: sc-117752 (A) and mouse IL-23 transfected: sc-121044 (B) 293T whole cell lysates.

IL-23 (D-12) - sc-271349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-23 (D-12): sc-271349. Western blot analysis of IL-23 expression in non-transfected: sc-117752 (A) and mouse IL-23 transfected: sc-121044 (B) 293T whole cell lysates.

IL-23 (G-20) - sc-21083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-23 (G-6) - sc-271280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-23 (G-6): sc-271280. Western blot analysis of IL-23 expression in non-transfected: sc-117752 (A) and mouse IL-23 transfected: sc-121044 (B) 293T whole cell lysates.

IL-23 (H-113) - sc-50303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-23 (H-113): sc-50303. Western blot analysis of IL-23 expression in non-transfected: sc-117752 (A) and mouse IL-23 transfected: sc-121044 (B) 293T whole cell lysates.

IL-23 (N-20) - sc-21079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL23 antibody - ab115759 from Abcam

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL23 antibody (ab115759) at 1 µg/mlLane 1 : Raji cell lysateLane 2 : Raji cell lysate

Anti-IL23 antibody - ab172501 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IL23 antibody (ab172501) at 1 µg/mlLane 1 : IL23 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-IL23 antibody [B-Z23] - ab84471 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-Z23
ab84472 used in Neutralisation.A = untreatedB = treated with IL-2 (10ng/ml) + IL-23 (10ng)C = treated with IL-2 (10ng/ml) + IL-23 (50ng/ml)D = treated with anti-IL-23 (5µg/ml) + IL-2 + IL-23 (50ng/ml)Human monocytes were fixed in methanol, permeabilized using 0.1% Saponin/ PBS, blocked with 4% serum for 30 minutes at 25°C and then incubated with ab84471 at 5µg/ml for 48 hours at 37°C.Staining: IL-17 (red) GFP (green).We have examined the effect of IL-23 and in combination with anti-IL-23 on IL-17 production in monocytes. IL-23 leads to increased IL-17 secretion (Figure B and C) and this effect was abolished with anti-IL-23 (Figure D). IL-2 is part of our culture medium for monocytes. IL-2 stimulation serves as a basis to keep the cell alive. Thus almost every cytokine that we used is used in combination with IL-2. Because it is part of the medium, IL-2 can be omitted when specifying the stimulation. The cells were stained with the GFP (Green Fluorescent Protein), just to make them visi

Anti-IL23 antibody [EPR5585(N)] - C-terminal - ab190356 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5585(N)
All lanes : Anti-IL23 antibody [EPR5585(N)] - C-terminal (ab190356) at 1/1000 dilutionLane 1 : THP-1 treated with GM-CSF+IL-4 cell lysateLane 2 : Untreated THP-1 cell lysateLane 3 : Raji cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-IL23 antibody - N-terminal - ab189300 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling IL23 with ab189300 at 5 µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IL23 antibody - N-terminal - ab200081 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-IL23 P19 antibody - ab45420 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL23 P19 antibody (ab45420) at 1 µg/mlLane 1 : Raji lysateLane 2 : Raji lysate with IL23 P19 blocking peptide

Anti-IL23 P19 antibody - ab41545 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL23 P19 antibody - ab42120 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL23 P19 antibody [HLT2736] - ab110630 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone HLT2736
Immunohistological staining of Human Adrenal tissue, Formalin-Fixed, Paraffin-Embedded using ab110630 at 10µg/ml dilution.

Anti-IL23A / IL-23 p19 Antibody - LS-C16056 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µg
Host Rat
Clonality Monoclonal

Anti-IL23A / IL-23 p19 Antibody - LS-C16057 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µg
Host Rat
Clonality Monoclonal

Anti-IL23A / IL-23 p19 Antibody - LS-C310761 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IL23 Antibody (aa20-189, FITC) - LS-C301722 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL23 Antibody (aa20-189, Biotin) - LS-C298549 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL23A / IL-23 p19 Antibody - LS-C308467 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IL23A / IL-23 p19 Antibody - LS-C310762 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL23A / IL-23 p19 Antibody (aa29-48) - LS-C312628 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of IL23A / IL-23 p19 antibody. Lane 1: Recombinant Mouse IL-23 Protein 10ng. Lane 2: Recombinant Mouse IL-23 Protein 5ng. Lane3 : Recombinant Mouse IL-23 Protein 2.5ng..

Anti-IL23 Antibody (aa20-189) - LS-C294891 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL23A / IL-23 p19.
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