| Gene Symbol | IL23A |
|---|---|
| Entrez Gene | 51561 |
| Alt Symbol | IL-23, IL-23A, IL23P19, P19, SGRF |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 23, alpha subunit p19 |
| Other Description | IL-23 subunit alpha|IL-23-A|IL-23p19|JKA3 induced upon T-cell activation|interleukin 23 p19 subunit|interleukin-23 subunit alpha|interleukin-23 subunit p19|interleukin-six, G-CSF related factor |
| Swissprots | Q9H2A5 Q6NZ82 Q6NZ80 Q9NPF7 |
| Accessions | BAA93687 CAM82731 CBX47553 CCA63964 EAW96933 Q9NPF7 AB030000 BAA93686 AF301620 AAG37232 AJ506993 CAD45088 AY359083 AAQ89442 BC066267 AAH66267 BC066268 AAH66268 BC066269 AAH66269 BC067511 AAH67511 BC067512 AAH67512 BC067513 AAH67513 BM842783 BM851337 HQ447589 ADQ32075 U38443 XM_011538477 XP_011536779 NM_016584 NP_057668 |
| Function | Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B. |
| Tissue Specificity | Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Rheumatoid arthritis, Pertussis, Tuberculosis |
IL-23 CRISPR/Cas9 KO Plasmid (h) - sc-401374 from Santa Cruz Biotechnology
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IL-23 HDR Plasmid (h) - sc-401374-HDR from Santa Cruz Biotechnology
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IL-23 Double Nickase Plasmid (h) - sc-401374-NIC from Santa Cruz Biotechnology
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IL-23 Double Nickase Plasmid (h2) - sc-401374-NIC-2 from Santa Cruz Biotechnology
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IL-23 CRISPR Activation Plasmid (h) - sc-401374-ACT from Santa Cruz Biotechnology
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IL-23 CRISPR Activation Plasmid (h2) - sc-401374-ACT-2 from Santa Cruz Biotechnology
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IL-23 Lentiviral Activation Particles (h) - sc-401374-LAC from Santa Cruz Biotechnology
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IL-23 Lentiviral Activation Particles (h2) - sc-401374-LAC-2 from Santa Cruz Biotechnology
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IL-23 siRNA (h) - sc-43860 from Santa Cruz Biotechnology
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IL-23 shRNA Plasmid (h) - sc-43860-SH from Santa Cruz Biotechnology
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IL-23 shRNA (h) Lentiviral Particles - sc-43860-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1151 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02237 from Sigma-Aldrich
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IL23A siRNA (Human) - CRH9833 from Cohesion Biosciences
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IL23A - MBS8233485 from MyBioSource
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shRNA set against Human IL23A (NM_016584.2) - SHH318749 from Creative biogene
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shRNA set against Human IL23A(NM_016584.2) - SHL172836 from Creative biogene
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Human IL23A siRNA - orb270335 from Biorbyt
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IL23A shRNA Plasmid (Human) - CHH9833 from Cohesion Biosciences
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IL23A miRNA 3'UTR clone - MiUTR1H-04909 from Creative biogene
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