IL23A

Gene Symbol	IL23A
Entrez Gene	51561
Alt Symbol	IL-23, IL-23A, IL23P19, P19, SGRF
Species	Human
Gene Type	protein-coding
Description	interleukin 23, alpha subunit p19
Other Description	IL-23 subunit alpha|IL-23-A|IL-23p19|JKA3 induced upon T-cell activation|interleukin 23 p19 subunit|interleukin-23 subunit alpha|interleukin-23 subunit p19|interleukin-six, G-CSF related factor
Swissprots	Q9H2A5 Q6NZ82 Q6NZ80 Q9NPF7
Accessions	BAA93687 CAM82731 CBX47553 CCA63964 EAW96933 Q9NPF7 AB030000 BAA93686 AF301620 AAG37232 AJ506993 CAD45088 AY359083 AAQ89442 BC066267 AAH66267 BC066268 AAH66268 BC066269 AAH66269 BC067511 AAH67511 BC067512 AAH67512 BC067513 AAH67513 BM842783 BM851337 HQ447589 ADQ32075 U38443 XM_011538477 XP_011536779 NM_016584 NP_057668
Function	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
Tissue Specificity	Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Rheumatoid arthritis, Pertussis, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL23 full length protein - ab106889 from Abcam Category Protein Prices $110.00, $210.00 Sizes 2 µg, 10 µg Source High-5 insect cells Species Human

Cow IL23 P19 full length protein - ab87524 from Abcam Category Protein Prices $252.00 Sizes 25 µg Source Yeast Species Bovine

Human IL23 full length protein - ab162592 from Abcam Category Protein Source Wheat germ Species Human

Human IL23 full length protein - ab109153 from Abcam Category Protein Source HEK 293 cells Species Human

Human IL23 P19 peptide - ab91437 from Abcam Category Peptide

IL23A / IL-23 p19 Antibody Blocking Peptide - LS-E30232 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IL23A / IL-23 p19 Antibody Blocking Peptide - LS-E30231 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human IL-23A/IL-23 P19 Protein - H00051561-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IL-23A/IL-23 P19 Blocking Peptide - NBP1-77257PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IL-23A/IL-23 P19 Blocking Peptide - NBP1-76697PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IL23 Peptide - GTX85495-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

IL23 Peptide - GTX85496-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Mouse IL-23 - 1887-ML-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (stably transfected)-derived

Recombinant Mouse IL-23, CF - 1887-ML-010/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (stably transfected)-derived

Recombinant Human IL-23 - 1290-IL-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Human IL-23, CF - 1290-IL-010/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Rat IL-23 - 3136-RL-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Rat IL-23, CF - 3136-RL-010/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Human IL 23 protein - orb168629 from Biorbyt Category Protein Prices $187.00, $323.00 Sizes 2 μg, 10 μg Species Human, Mouse

Human IL-23 (His Tag) protein - orb232788 from Biorbyt Category Protein Prices $238.00, $323.00, $646.00, $1,063.00 Sizes 5 μg, 10 μg, 50 μg, 100 μg Species Human

Human IL 23 (His tag) protein - orb168630 from Biorbyt Category Protein Prices $230.00, $442.00, $1,828.00 Sizes 2 μg, 10 μg, 100 μg Source HEK 293 cells. Species Human

Human Interleukin 23 Protein - abx067509 from Abbexa Category Protein Source E.coli Species Human

Interleukin-23 / IL23 - AR20010PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source Insect cells Species Human

Interleukin-23 / IL23 - AR20010PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source Insect cells Species Human

Interleukin-23 alpha / IL23A - H00051561-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Search more