IL23A

Gene Symbol	IL23A
Entrez Gene	51561
Alt Symbol	IL-23, IL-23A, IL23P19, P19, SGRF
Species	Human
Gene Type	protein-coding
Description	interleukin 23, alpha subunit p19
Other Description	IL-23 subunit alpha|IL-23-A|IL-23p19|JKA3 induced upon T-cell activation|interleukin 23 p19 subunit|interleukin-23 subunit alpha|interleukin-23 subunit p19|interleukin-six, G-CSF related factor
Swissprots	Q9H2A5 Q6NZ82 Q6NZ80 Q9NPF7
Accessions	BAA93687 CAM82731 CBX47553 CCA63964 EAW96933 Q9NPF7 AB030000 BAA93686 AF301620 AAG37232 AJ506993 CAD45088 AY359083 AAQ89442 BC066267 AAH66267 BC066268 AAH66268 BC066269 AAH66269 BC067511 AAH67511 BC067512 AAH67512 BC067513 AAH67513 BM842783 BM851337 HQ447589 ADQ32075 U38443 XM_011538477 XP_011536779 NM_016584 NP_057668
Function	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
Tissue Specificity	Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Rheumatoid arthritis, Pertussis, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL23A-Over-expression-Lysate - LY10230a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

IL23A 293T Cell Transient Overexpression Lysate(Denatured) - H00051561-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IL23A overexpression lysate - LY402570 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL23A 293 Cell Lysate - 402246 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IL-23A/IL-23 P19 Overexpression Lysate (Denatured) - H00051561-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

IL-23A/IL-23 P19 Overexpression Lysate (Native) - NBL1-11943 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL23A Over-expression Lysate Product - GWB-14063C from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human IL-23A & IL-12B Heterodimer HEK293 Cell Lysate (WB positive control) - CT012-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL-23 Human Cells Transfected Lysate (positive control) (denatured) - orb233536 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human IL23A Knockdown Stable Cell Line - CSC-DC007579 from Creative biogene Category Cell Line Species Human

Search more