| Gene Symbol |
MASTL
|
| Entrez Gene |
84930
|
| Alt Symbol |
GREATWALL, GW, GWL, MAST-L, THC2, hGWL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule associated serine/threonine kinase-like
|
| Other Description |
greatwall kinase homolog|greatwall protein kinase|microtubule-associated serine/threonine-protein kinase-like|serine/threonine-protein kinase greatwall
|
| Swissprots |
Q5T8D7 Q8NCD6 Q5T8D5 Q96SJ5 Q96GX5
|
| Accessions |
EAW86064 EAW86065 EAW86066 EAW86067 Q96GX5 AK027719 BAB55321 AK074804 BAC11218 AK123004 AK225319 AW408392 AW675108 BC009107 AAH09107 BC013704 BU430288 DA524606 DB150802 XM_005252630 XP_005252687 XM_005252631 XP_005252688 XM_005252632 XP_005252689 XM_006717518 XP_006717581 XM_006717519 XP_006717582 XM_006717520 XP_006717583 XM_011519751 XP_011518053 XR_930523 NM_001172303 NP_001165774 NM_001172304 NP_001165775 NM_032844 NP_116233
|
| Function |
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow.
|