MASTL

Gene Symbol	MASTL
Entrez Gene	84930
Alt Symbol	GREATWALL, GW, GWL, MAST-L, THC2, hGWL
Species	Human
Gene Type	protein-coding
Description	microtubule associated serine/threonine kinase-like
Other Description	greatwall kinase homolog|greatwall protein kinase|microtubule-associated serine/threonine-protein kinase-like|serine/threonine-protein kinase greatwall
Swissprots	Q5T8D7 Q8NCD6 Q5T8D5 Q96SJ5 Q96GX5
Accessions	EAW86064 EAW86065 EAW86066 EAW86067 Q96GX5 AK027719 BAB55321 AK074804 BAC11218 AK123004 AK225319 AW408392 AW675108 BC009107 AAH09107 BC013704 BU430288 DA524606 DB150802 XM_005252630 XP_005252687 XM_005252631 XP_005252688 XM_005252632 XP_005252689 XM_006717518 XP_006717581 XM_006717519 XP_006717582 XM_006717520 XP_006717583 XM_011519751 XP_011518053 XR_930523 NM_001172303 NP_001165774 NM_001172304 NP_001165775 NM_032844 NP_116233
Function	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MASTL gene - orb91256 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human MASTL cDNA clone(NM_001172303.1) - CDFH011122 from Creative Biomart Species Human Accession NM_001172303.1

Human MASTL cDNA clone(NM_001172304.1) - CDFH011123 from Creative Biomart Species Human Accession NM_001172304.1

Human MASTL ORF Clone(NM_001172303.1) - CDCL169669 from Creative Biomart Species Human Accession NM_001172303.1

Human MASTL ORF Clone(NM_001172303.1) - CDCR356486 from Creative Biomart Species Human Accession NM_001172303.1

Human MASTL ORF Clone(NM_001172304.1) - CDCR356487 from Creative Biomart Species Human Accession NM_001172304.1

Human MASTL ORF Clone(NM_001172304.1) - CDCR356488 from Creative Biomart Species Human Accession NM_001172304.1

Human MASTL ORF Clone(NM_001172303.1) - CDCR356490 from Creative Biomart Species Human Accession NM_001172303.1

Human MASTL/THC2 Gene ORF cDNA clone in cloning vector - HG10761-M from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10761-NF from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10761-NM from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10761-CF from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10761-CY from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10761-NH from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10761-M-F from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10761-CM from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10761-NY from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10761-ANG from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10761-CH from Sino Biological Species Human

Human MASTL / THC2 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10761-M-N from Sino Biological Species Human Accession NM_032844.2

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10761-ACR from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10761-ANR from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10761-ACG from Sino Biological Species Human

Human MASTL/THC2 Gene ORF cDNA clone expression plasmid - HG10761-UT from Sino Biological Species Human

Human MASTL ORF Clone(NM_001172303.1) - CDCR356486 from Creative biogene Species Human

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