MASTL

Gene Symbol	MASTL
Entrez Gene	84930
Alt Symbol	GREATWALL, GW, GWL, MAST-L, THC2, hGWL
Species	Human
Gene Type	protein-coding
Description	microtubule associated serine/threonine kinase-like
Other Description	greatwall kinase homolog|greatwall protein kinase|microtubule-associated serine/threonine-protein kinase-like|serine/threonine-protein kinase greatwall
Swissprots	Q5T8D7 Q8NCD6 Q5T8D5 Q96SJ5 Q96GX5
Accessions	EAW86064 EAW86065 EAW86066 EAW86067 Q96GX5 AK027719 BAB55321 AK074804 BAC11218 AK123004 AK225319 AW408392 AW675108 BC009107 AAH09107 BC013704 BU430288 DA524606 DB150802 XM_005252630 XP_005252687 XM_005252631 XP_005252688 XM_005252632 XP_005252689 XM_006717518 XP_006717581 XM_006717519 XP_006717582 XM_006717520 XP_006717583 XM_011519751 XP_011518053 XR_930523 NM_001172303 NP_001165774 NM_001172304 NP_001165775 NM_032844 NP_116233
Function	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MASTL full length protein - ab164698 from Abcam Category Protein Source Wheat germ Species Human

Human MASTL protein fragment - ab164699 from Abcam Category Protein Source Wheat germ Species Human

MASTL / GW Antibody Blocking Peptide - LS-E3148 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MASTL / GW Antibody Blocking Peptide - LS-E22205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MASTL Protein - H00084930-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MASTL Protein - H00084930-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MASTL Blocking Peptide - 33R-6740 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MASTL - H00084930-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MASTL - H00084930-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MASTL - H00084930-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MASTL - H00084930-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MASTL fusion protein - Ag9662 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MASTL fusion protein - ag9397 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MASTL, His-tagged - MASTL-757H from Creative Biomart Category Protein Source E.coli Species Human

GW Blocking Peptide - CBP4081 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Bovine, Chicken, Dog

MASTL (P833) Peptide - BS9190P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Serine/threonine-protein kinase greatwall(MASTL) ,partial - CSB-YP846629HU CSB-EP846629HU CSB-BP846629HU CSB-MP846629HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MASTL - TP303858 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GW Blocking Peptide - abx162574 from Abbexa Category Peptide Species Human, Mouse, Bovine, Chicken, Dog

MASTL Recombinant Protein Antigen - NBP1-83680PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MASTL-Antibody-N-term-Blocking-Peptide - BP7147a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MASTL Peptide, Human - M34GP09252H from Creative Peptides Category Peptide Source Synthetic. Species Human

MASTL Recombinant Protein Antigen - NBP2-55023PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Serine/threonine-protein kinase greatwall (MASTL), partial, Recombinant Protein - MBS1429770 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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