STK24

Gene Symbol	STK24
Entrez Gene	8428
Alt Symbol	HEL-S-95, MST3, MST3B, STE20, STK3
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 24
Other Description	STE20-like kinase 3|STE20-like kinase MST3|epididymis secretory protein Li 95|mammalian STE20-like protein kinase 3|serine/threonine kinase 24 (STE20 homolog, yeast)|serine/threonine-protein kinase 24|sterile 20-like kinase 3
Swissprots	O14840 Q5JV92 Q9Y6E0
Accessions	CCQ43220 EAX08985 EAX08986 EAX08987 Q9Y6E0 AF024636 AAB82560 AF083420 AAD42039 AF339826 AK297583 BAG59972 AK299140 BAG61192 BC035578 AAH35578 BC065378 AAH65378 BT019619 AAV38425 CB996892 CR542227 CAG47023 DA386652 DA395717 DB479387 DQ890912 ABM81838 EU668350 ACF94503 XM_005254078 XP_005254135 XM_005254079 XP_005254136 NM_001032296 NP_001027467 NM_001286649 NP_001273578 NM_003576 NP_003567
Function	Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:1985
Subcellular Location	Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Tissue Specificity	Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STK24-Over-expression-Lysate - LY10725a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

STK24 overexpression lysate - LY418583 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MST-3 (h): 293T Lysate - sc-115276 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MST-3 (h3): 293 Lysate - sc-158745 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Human STK24 / MST3 Insect Cell Lysate (WB positive control) - 13188-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

MST3 Overexpression Lysate (Native) - NBP2-10596 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Human STK24 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175124 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human STK24 Knockdown Stable Cell Line - CSC-DC015309 from Creative biogene Category Cell Line Species Human

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