| Gene Symbol |
STK24
|
| Entrez Gene |
8428
|
| Alt Symbol |
HEL-S-95, MST3, MST3B, STE20, STK3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/threonine kinase 24
|
| Other Description |
STE20-like kinase 3|STE20-like kinase MST3|epididymis secretory protein Li 95|mammalian STE20-like protein kinase 3|serine/threonine kinase 24 (STE20 homolog, yeast)|serine/threonine-protein kinase 24|sterile 20-like kinase 3
|
| Swissprots |
O14840 Q5JV92 Q9Y6E0
|
| Accessions |
CCQ43220 EAX08985 EAX08986 EAX08987 Q9Y6E0 AF024636 AAB82560 AF083420 AAD42039 AF339826 AK297583 BAG59972 AK299140 BAG61192 BC035578 AAH35578 BC065378 AAH65378 BT019619 AAV38425 CB996892 CR542227 CAG47023 DA386652 DA395717 DB479387 DQ890912 ABM81838 EU668350 ACF94503 XM_005254078 XP_005254135 XM_005254079 XP_005254136 NM_001032296 NP_001027467 NM_001286649 NP_001273578 NM_003576 NP_003567
|
| Function |
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:1985
|
| Subcellular Location |
Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
|
| Tissue Specificity |
Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
|