STK24

Gene Symbol STK24
Entrez Gene 8428
Alt Symbol HEL-S-95, MST3, MST3B, STE20, STK3
Species Human
Gene Type protein-coding
Description serine/threonine kinase 24
Other Description STE20-like kinase 3|STE20-like kinase MST3|epididymis secretory protein Li 95|mammalian STE20-like protein kinase 3|serine/threonine kinase 24 (STE20 homolog, yeast)|serine/threonine-protein kinase 24|sterile 20-like kinase 3
Swissprots O14840 Q5JV92 Q9Y6E0
Accessions CCQ43220 EAX08985 EAX08986 EAX08987 Q9Y6E0 AF024636 AAB82560 AF083420 AAD42039 AF339826 AK297583 BAG59972 AK299140 BAG61192 BC035578 AAH35578 BC065378 AAH65378 BT019619 AAV38425 CB996892 CR542227 CAG47023 DA386652 DA395717 DB479387 DQ890912 ABM81838 EU668350 ACF94503 XM_005254078 XP_005254135 XM_005254079 XP_005254136 NM_001032296 NP_001027467 NM_001286649 NP_001273578 NM_003576 NP_003567
Function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:1985
Subcellular Location Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Tissue Specificity Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

MST3 Antibody - 3723 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MST3 Antibody.

MST3b Antibody - 4062 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MST3b Antibody.

MST-3 (E-17) - sc-21400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MST-3 (E-17): sc-21400. Western blot analysis of MST-3 expression in Jurkat (A), Jurkat +FAS (B), KNRK (C) and A-431 (D) whole cell lysates.

MST-3 (47) - sc-135993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
MST-3 (47): sc-135993. Western blot analysis of MST-3 expression in A-431 whole cell lysate.

Anti-MST3 antibody - ab96705 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MST3 antibody (ab96705) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-MST3 antibody - ab155198 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MST3 antibody (ab155198) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : H1299 whole cell lysateLane 4 : HeLaS3 whole cell lysateLane 5 : HepG2 whole cell lysateLane 6 : MOLT4 whole cell lysateLane 7 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-MST3 antibody - ab138269 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MST3 antibody (ab138269) at 1/500 dilution + COLO205 cells at 30 µg

Anti-MST3 antibody [EP1468Y] - ab51137 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1468Y
Anti-MST3 antibody [EP1468Y] (ab51137) at 1/5000 dilution + HeLa cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-MST3 antibody - N-terminal - ab199880 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-MST3 antibody - N-terminal (ab199880) at 1/1000 dilution + mouse thymus total cell extract

Anti-STK24 / MST3 Antibody (N-Terminus) - LS-C16616 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa325-375) - LS-C72830 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa356-375) - LS-C147885 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa221-249, AP) - LS-C270552 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa221-249, APC) - LS-C270553 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa221-249, Biotin) - LS-C270554 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa302-351) - LS-C200731 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from COLO205 cells using STK24 antibody.

Anti-STK24 / MST3 Antibody (aa221-249, FITC) - LS-C270556 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa221-249, Azide-free, HRP) - LS-C270557 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (aa221-249, PE) - LS-C270559 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (C-Terminus, AP) - LS-C279717 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (C-Terminus, APC) - LS-C279718 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (clone 1E12) - LS-C198560 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E12
Detection limit for recombinant GST tagged STK24 is approximately 3 ng/ml as a capture antibody.

Anti-STK24 / MST3 Antibody (C-Terminus, Biotin) - LS-C279719 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (C-Terminus, FITC) - LS-C279720 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK24 / MST3 Antibody (C-Terminus) - LS-C99495 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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