STK24

Gene Symbol	STK24
Entrez Gene	8428
Alt Symbol	HEL-S-95, MST3, MST3B, STE20, STK3
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 24
Other Description	STE20-like kinase 3|STE20-like kinase MST3|epididymis secretory protein Li 95|mammalian STE20-like protein kinase 3|serine/threonine kinase 24 (STE20 homolog, yeast)|serine/threonine-protein kinase 24|sterile 20-like kinase 3
Swissprots	O14840 Q5JV92 Q9Y6E0
Accessions	CCQ43220 EAX08985 EAX08986 EAX08987 Q9Y6E0 AF024636 AAB82560 AF083420 AAD42039 AF339826 AK297583 BAG59972 AK299140 BAG61192 BC035578 AAH35578 BC065378 AAH65378 BT019619 AAV38425 CB996892 CR542227 CAG47023 DA386652 DA395717 DB479387 DQ890912 ABM81838 EU668350 ACF94503 XM_005254078 XP_005254135 XM_005254079 XP_005254136 NM_001032296 NP_001027467 NM_001286649 NP_001273578 NM_003576 NP_003567
Function	Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:1985
Subcellular Location	Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Tissue Specificity	Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MST-3 CRISPR/Cas9 KO Plasmid (h) - sc-406440 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 HDR Plasmid (h) - sc-406440-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 Double Nickase Plasmid (h) - sc-406440-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 Double Nickase Plasmid (h2) - sc-406440-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 CRISPR Activation Plasmid (h) - sc-406440-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 CRISPR Activation Plasmid (h2) - sc-406440-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 Lentiviral Activation Particles (h) - sc-406440-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 Lentiviral Activation Particles (h2) - sc-406440-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MST-3 siRNA (h) - sc-39251 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MST-3 shRNA Plasmid (h) - sc-39251-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MST-3 shRNA (h) Lentiviral Particles - sc-39251-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MST3 RNAi - H00008428-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU110681 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2155 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2153 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2154 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN20734 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20734 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

STK24 siRNA (Human) - CRH5521 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK24 - MBS8217000 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human STK24 (NM_003576.3) - SHH419752 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human STK24(NM_003576.3) - SHL034356 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human STK24(NM_001032296.2) - SHL034410 from Creative biogene Category siRNA Species Reactivities Human

Human STK24 siRNA - orb266023 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK24 shRNA Plasmid (Human) - CHH5521 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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