STK24

Gene Symbol	STK24
Entrez Gene	8428
Alt Symbol	HEL-S-95, MST3, MST3B, STE20, STK3
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 24
Other Description	STE20-like kinase 3|STE20-like kinase MST3|epididymis secretory protein Li 95|mammalian STE20-like protein kinase 3|serine/threonine kinase 24 (STE20 homolog, yeast)|serine/threonine-protein kinase 24|sterile 20-like kinase 3
Swissprots	O14840 Q5JV92 Q9Y6E0
Accessions	CCQ43220 EAX08985 EAX08986 EAX08987 Q9Y6E0 AF024636 AAB82560 AF083420 AAD42039 AF339826 AK297583 BAG59972 AK299140 BAG61192 BC035578 AAH35578 BC065378 AAH65378 BT019619 AAV38425 CB996892 CR542227 CAG47023 DA386652 DA395717 DB479387 DQ890912 ABM81838 EU668350 ACF94503 XM_005254078 XP_005254135 XM_005254079 XP_005254136 NM_001032296 NP_001027467 NM_001286649 NP_001273578 NM_003576 NP_003567
Function	Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:1985
Subcellular Location	Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Tissue Specificity	Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MST3 protein fragment - ab51413 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human MST3 full length protein - ab132980 from Abcam Category Protein Source Wheat germ Species Human

Human MST3 peptide - ab198164 from Abcam Category Peptide Species Human

STK24 / MST3 Antibody Blocking Peptide - LS-E5530 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK24 / MST3 Antibody Blocking Peptide - LS-E9371 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MST3 Recombinant Protein - H00008428-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MST3 Protein - P3924 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

MST3 Peptide - P2909 from Novus Biologicals Category Peptide Species Human

MST3-Antibody-C-term-Blocking-Peptide - BP7924a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human STK24 protein (His Tag) - orb139708 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

STK24 / STK3 - H00008428-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

STK24 / STK3 - H00008428-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

STK24 / STK3 - P3924 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

STK24 fusion protein - ag4483 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human STK24, GST-tagged, Active - STK24-362H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human STK24, His tagged - STK24-1359H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

MST3 Protein, active, 250 µg - 14-695M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-695) and in bulk (cat#14-695-K) Source expressed by baculovirus in Sf21 cells

MST3 Protein, active, 10 µg - 14-695 from EMD Millipore Category Protein Prices $311.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

Recombinant Candida albicans Serine/threonine-protein kinase CST20(CST20) ,partial - CSB-YP317856CZF CSB-EP317856CZF CSB-BP317856CZF CSB-MP317856CZF from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Candida

MST3 Blocking Peptide - CBP4261 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

MST3 Blocking Peptide - abx161472 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

STK24 / STK3 (transcript variant 1) - TP317776 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human STK24 / MST3 Protein (His Tag) - 13188-H07B-20 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human STK24 / MST3 Protein (His tag) - PKSH030330 from Elabscience Category Protein Source Baculoviru Species Human

MST3 Recombinant Protein Antigen - NBP1-87834PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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