| Gene Symbol |
ATG4A
|
| Entrez Gene |
115201
|
| Alt Symbol |
APG4A, AUTL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autophagy related 4A, cysteine peptidase
|
| Other Description |
APG4 autophagy 4 homolog A|ATG4 autophagy related 4 homolog A|AUT-like 2 cysteine endopeptidase|AUT-like 2, cysteine endopeptidase|autophagin 2|autophagin-2|autophagy-related cysteine endopeptidase 2|autophagy-related protein 4 homolog A|cysteine protease ATG4A|hAPG4A
|
| Swissprots |
O95534 Q8WYN0 D3DUY0 A6NCH2 Q5JYY9 B2RAZ7 Q5JYZ0 Q96KQ1 Q86VE5 Q96KQ0
|
| Accessions |
EAX02689 EAX02690 EAX02691 EAX02692 EAX02693 EAX02694 EAX02695 EAX02696 Q8WYN0 AA648264 AB066214 BAB83889 AJ320508 CAC69076 AJ320509 CAC69077 AJ504651 CAD43218 AK054927 AK123287 AK293533 BAG57015 AK314429 BAG37044 BC041862 AAH41862 BC061696 AAH61696 BM541631 HQ447703 ADQ32188 XM_005262064 XP_005262121 XM_011530840 XP_011529142 XM_011530841 XP_011529143 XM_011530842 XP_011529144 XM_011530843 XP_011529145 XM_011530844 XP_011529146 XM_011530845 XP_011529147 NM_052936 NP_443168 NM_178270 NP_840054 NM_178271
|
| Function |
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269|PubMed:12473658, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:21245471, ECO:0000269|PubMed:22302004}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. {ECO:0000269|PubMed:12446702, ECO:0000269|PubMed:15169837}.
|
| Top Pathways |
Regulation of autophagy
|