ATG4A

Gene Symbol	ATG4A
Entrez Gene	115201
Alt Symbol	APG4A, AUTL2
Species	Human
Gene Type	protein-coding
Description	autophagy related 4A, cysteine peptidase
Other Description	APG4 autophagy 4 homolog A|ATG4 autophagy related 4 homolog A|AUT-like 2 cysteine endopeptidase|AUT-like 2, cysteine endopeptidase|autophagin 2|autophagin-2|autophagy-related cysteine endopeptidase 2|autophagy-related protein 4 homolog A|cysteine protease ATG4A|hAPG4A
Swissprots	O95534 Q8WYN0 D3DUY0 A6NCH2 Q5JYY9 B2RAZ7 Q5JYZ0 Q96KQ1 Q86VE5 Q96KQ0
Accessions	EAX02689 EAX02690 EAX02691 EAX02692 EAX02693 EAX02694 EAX02695 EAX02696 Q8WYN0 AA648264 AB066214 BAB83889 AJ320508 CAC69076 AJ320509 CAC69077 AJ504651 CAD43218 AK054927 AK123287 AK293533 BAG57015 AK314429 BAG37044 BC041862 AAH41862 BC061696 AAH61696 BM541631 HQ447703 ADQ32188 XM_005262064 XP_005262121 XM_011530840 XP_011529142 XM_011530841 XP_011529143 XM_011530842 XP_011529144 XM_011530843 XP_011529145 XM_011530844 XP_011529146 XM_011530845 XP_011529147 NM_052936 NP_443168 NM_178270 NP_840054 NM_178271
Function	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269|PubMed:12473658, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:21245471, ECO:0000269|PubMed:22302004}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. {ECO:0000269|PubMed:12446702, ECO:0000269|PubMed:15169837}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Atg4A siRNA I - 6427 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Atg4a CRISPR/Cas9 KO Plasmid (h) - sc-417880 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a HDR Plasmid (h) - sc-417880-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a Double Nickase Plasmid (h) - sc-417880-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a Double Nickase Plasmid (h2) - sc-417880-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a CRISPR Activation Plasmid (h) - sc-417880-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a CRISPR Activation Plasmid (h2) - sc-417880-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a Lentiviral Activation Particles (h) - sc-417880-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a Lentiviral Activation Particles (h2) - sc-417880-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4a siRNA (h) - sc-91197 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Atg4a shRNA Plasmid (h) - sc-91197-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Atg4a shRNA (h) Lentiviral Particles - sc-91197-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU135061 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3651 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3651 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07461 from Sigma-Aldrich Category miRNA

ATG4A siRNA (Human) - CRJ4433 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATG4A - MBS826884 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ATG4A (NM_052936.3) - SHH242118 from Creative biogene Category siRNA Species Reactivities Human

ATG4A shRNA Plasmid (Human) - CHJ4433 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATG4A miRNA 3'UTR clone - MiUTR3H-02892 from Creative biogene Species Reactivities Human

ATG4A miRNA 3'UTR clone - MiUTR3H-02893 from Creative biogene Species Reactivities Human

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