ATG4A

Gene Symbol	ATG4A
Entrez Gene	115201
Alt Symbol	APG4A, AUTL2
Species	Human
Gene Type	protein-coding
Description	autophagy related 4A, cysteine peptidase
Other Description	APG4 autophagy 4 homolog A|ATG4 autophagy related 4 homolog A|AUT-like 2 cysteine endopeptidase|AUT-like 2, cysteine endopeptidase|autophagin 2|autophagin-2|autophagy-related cysteine endopeptidase 2|autophagy-related protein 4 homolog A|cysteine protease ATG4A|hAPG4A
Swissprots	O95534 Q8WYN0 D3DUY0 A6NCH2 Q5JYY9 B2RAZ7 Q5JYZ0 Q96KQ1 Q86VE5 Q96KQ0
Accessions	EAX02689 EAX02690 EAX02691 EAX02692 EAX02693 EAX02694 EAX02695 EAX02696 Q8WYN0 AA648264 AB066214 BAB83889 AJ320508 CAC69076 AJ320509 CAC69077 AJ504651 CAD43218 AK054927 AK123287 AK293533 BAG57015 AK314429 BAG37044 BC041862 AAH41862 BC061696 AAH61696 BM541631 HQ447703 ADQ32188 XM_005262064 XP_005262121 XM_011530840 XP_011529142 XM_011530841 XP_011529143 XM_011530842 XP_011529144 XM_011530843 XP_011529145 XM_011530844 XP_011529146 XM_011530845 XP_011529147 NM_052936 NP_443168 NM_178270 NP_840054 NM_178271
Function	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269|PubMed:12473658, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:21245471, ECO:0000269|PubMed:22302004}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. {ECO:0000269|PubMed:12446702, ECO:0000269|PubMed:15169837}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATG4A full length protein - ab165064 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ATG4A full length protein - ab172826 from Abcam Category Protein Prices $210.00 Sizes 10 µg Source E. coli Species Human

ATG4A Antibody Blocking Peptide - LS-E5563 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG4A Antibody Blocking Peptide - LS-E5564 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG4A Antibody Blocking Peptide - LS-E15733 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ATG4A Protein - H00115201-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

APG4A-Antibody-C-term-Blocking-Peptide - BP1808c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG4A-Antibody-N-term-Blocking-Peptide - BP1808a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ATG4A protein - orb163487 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

ATG4A Blocking Peptide - 33R-7312 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ATG4A Blocking Peptide - 33R-1853 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Autophagin-2 - H00115201-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Autophagin-2 - H00115201-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ATG4A, Human, Recombinant - 19-CF50 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

ATG4A Peptide - 8071P from ProSci Category Peptide Species Human

Recombinant Human ATG4A Enzyme - BP001789-CF50 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human ATG4A, His-tagged - ATG4A-36H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Cysteine protease ATG4A(ATG4A) - CSB-YP845174HU CSB-EP845174HU CSB-BP845174HU CSB-MP845174HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ATG4A Recombinant Protein Antigen - NBP1-89044PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

APG4A-Antibody-Center-Blocking-Peptide - BP1808b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-ATG4AS100-Antibody-Blocking-peptide - BP3455a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

ATG4A Peptide, Human - M34GP01101H from Creative Peptides Category Peptide Source Synthetic. Species Human

Autophagy protein 4A Recombinant Protein - 92-103 from ProSci Category Protein Prices $575.00 Sizes 50 µg Source E. coli Species Human

Human ATG4A protein - orb391268 from Biorbyt Category Protein Prices $374.00, $901.00, $3,536.00 Sizes 10 μl (Trial size), 50 μl, 500 μl Species Human

ATG4A Recombinant Protein Antigen - NBP2-56465PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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