ATG4A

Gene Symbol ATG4A
Entrez Gene 115201
Alt Symbol APG4A, AUTL2
Species Human
Gene Type protein-coding
Description autophagy related 4A, cysteine peptidase
Other Description APG4 autophagy 4 homolog A|ATG4 autophagy related 4 homolog A|AUT-like 2 cysteine endopeptidase|AUT-like 2, cysteine endopeptidase|autophagin 2|autophagin-2|autophagy-related cysteine endopeptidase 2|autophagy-related protein 4 homolog A|cysteine protease ATG4A|hAPG4A
Swissprots O95534 Q8WYN0 D3DUY0 A6NCH2 Q5JYY9 B2RAZ7 Q5JYZ0 Q96KQ1 Q86VE5 Q96KQ0
Accessions EAX02689 EAX02690 EAX02691 EAX02692 EAX02693 EAX02694 EAX02695 EAX02696 Q8WYN0 AA648264 AB066214 BAB83889 AJ320508 CAC69076 AJ320509 CAC69077 AJ504651 CAD43218 AK054927 AK123287 AK293533 BAG57015 AK314429 BAG37044 BC041862 AAH41862 BC061696 AAH61696 BM541631 HQ447703 ADQ32188 XM_005262064 XP_005262121 XM_011530840 XP_011529142 XM_011530841 XP_011529143 XM_011530842 XP_011529144 XM_011530843 XP_011529145 XM_011530844 XP_011529146 XM_011530845 XP_011529147 NM_052936 NP_443168 NM_178270 NP_840054 NM_178271
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269|PubMed:12473658, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:21245471, ECO:0000269|PubMed:22302004}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. {ECO:0000269|PubMed:12446702, ECO:0000269|PubMed:15169837}.
Top Pathways Regulation of autophagy

PathScan ® Total SQSTM1/p62 Sandwich ELISA Kit - 7814 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1. SQSTM1/p62 protein from SK-MEL-2 cells is detected using PathScan ® Total SQSTM1/p62 Sandwich ELISA Kit #7814. This kit detects lower levels of SQSTM1/p62 in SK-MEL-2 cells starved overnight in Earle's Balanced Salt Solution (EBSS). The absorbance readings at 450 nm are shown in the top figure, while the corresponding western blot using SQSTM1/p62 (D5E2) Rabbit mAb #8025 is shown in the bottom figure.

Cysteine protease ATG4A (ATG4A), Human, ELISA Kit - E01C1203 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7250442 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7234611 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7231545 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7224400 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7216999 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7241862 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7228330 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7228590 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7245499 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7233216 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7250398 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cysteine protease ATG4A (ATG4A), ELISA Kit - MBS7223008 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ATG4A ELISA Kit - E010805 from Biobool

Category ELISA Kit

anti-ATG4A antibody - ARG54904 from Arigo Biolaboratories

Category ELISA Kit

anti-ATG4A antibody - ARG22623 from Arigo Biolaboratories

Category ELISA Kit

anti-ATG4A antibody - ARG54817 from Arigo Biolaboratories

Category ELISA Kit
Search more