| Gene Symbol |
PARVA
|
| Entrez Gene |
55742
|
| Alt Symbol |
CH-ILKBP, MXRA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
parvin, alpha
|
| Other Description |
actopaxin|alpha-parvin|calponin-like integrin-linked kinase-binding protein|matrix-remodeling-associated protein 2
|
| Swissprots |
Q96C85 Q9HA48 Q9NVD7
|
| Accessions |
EAW68523 EAW68524 EAW68525 Q9NVD7 AF237771 AAG27173 AF325830 AAK49911 AK001655 BAA91815 AK022316 BAB14009 AK057835 AK098504 AK128814 AK304444 BAH14188 BC014535 AAH14535 BC016713 AAH16713 DC344538 EU832601 ACE87003 HQ448212 ADQ32692 XM_005253015 XP_005253072 NM_018222 NP_060692
|
| Function |
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}.
|
| Subcellular Location |
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
|
| Tissue Specificity |
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:11722847}.
|
| Top Pathways |
Focal adhesion
|