PARVA

Gene Symbol	PARVA
Entrez Gene	55742
Alt Symbol	CH-ILKBP, MXRA2
Species	Human
Gene Type	protein-coding
Description	parvin, alpha
Other Description	actopaxin|alpha-parvin|calponin-like integrin-linked kinase-binding protein|matrix-remodeling-associated protein 2
Swissprots	Q96C85 Q9HA48 Q9NVD7
Accessions	EAW68523 EAW68524 EAW68525 Q9NVD7 AF237771 AAG27173 AF325830 AAK49911 AK001655 BAA91815 AK022316 BAB14009 AK057835 AK098504 AK128814 AK304444 BAH14188 BC014535 AAH14535 BC016713 AAH16713 DC344538 EU832601 ACE87003 HQ448212 ADQ32692 XM_005253015 XP_005253072 NM_018222 NP_060692
Function	Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}.
Subcellular Location	Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
Tissue Specificity	Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:11722847}.
Top Pathways	Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Parvin alpha full length protein - ab134616 from Abcam Category Protein Source E. coli Species Human

Human Parvin alpha full length protein - ab173045 from Abcam Category Protein Source E. coli Species Human

PARVA Antibody Blocking Peptide - LS-E6095 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARVA Antibody Blocking Peptide - LS-E10063 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Alpha-parvin/Actopaxin Recombinant Protein - H00055742-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Alpha-parvin/Actopaxin Recombinant Protein - H00055742-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Alpha-parvin/Actopaxin Protein - NBP2-23317 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

PARVA-Antibody-C-term-Blocking-Peptide - BP9318b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PARVA protein (GST Tag) - orb139451 from Biorbyt Category Protein Prices $417.00, $859.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human PARVA protein - orb163434 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human PARVA protein - orb168991 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

PARVA protein (His tag) - 80R-2516 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

PARVA (1-372, His-tag) - AR50588PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

PARVA (1-372, His-tag) - AR50588PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

PARVA - H00055742-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PARVA - H00055742-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PARVA - H00055742-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PARVA - H00055742-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PARVA - H00055742-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PARVA, 1-372aa, Human, His tag, E.coli - 01-P1764 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

PARVA, Human, Recombinant - 19-CE90 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

PARVA fusion protein - ag1694 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PARVA Human - PRPS-1264 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human PARVA Protein - BP001795-CE90 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

PARVA, 1-372aa, Recombinant Protein - GWB-P0274A from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

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