PARVA

Gene Symbol	PARVA
Entrez Gene	55742
Alt Symbol	CH-ILKBP, MXRA2
Species	Human
Gene Type	protein-coding
Description	parvin, alpha
Other Description	actopaxin\|alpha-parvin\|calponin-like integrin-linked kinase-binding protein\|matrix-remodeling-associated protein 2
Swissprots	Q96C85 Q9HA48 Q9NVD7
Accessions	EAW68523 EAW68524 EAW68525 Q9NVD7 AF237771 AAG27173 AF325830 AAK49911 AK001655 BAA91815 AK022316 BAB14009 AK057835 AK098504 AK128814 AK304444 BAH14188 BC014535 AAH14535 BC016713 AAH16713 DC344538 EU832601 ACE87003 HQ448212 ADQ32692 XM_005253015 XP_005253072 NM_018222 NP_060692
Function	Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269\|PubMed:11134073, ECO:0000269\|PubMed:11331308, ECO:0000269\|PubMed:15284246, ECO:0000269\|PubMed:20393563}.
Subcellular Location	Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
Tissue Specificity	Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. {ECO:0000269\|PubMed:11134073, ECO:0000269\|PubMed:11331308, ECO:0000269\|PubMed:11722847}.
Top Pathways	Focal adhesion

α-Parvin (D7F9) XP ® Rabbit mAb - 8190 from Cell Signaling Technology

Prices	$277.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D7F9

Western blot analysis of extracts from various cell lines using α-Parvin (D7F9) XP ® Rabbit mAb.

α-Parvin Antibody - 4026 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various cell types using α-Parvin Antibody. In lane 2, HeLa cells were isolated in mitosis by mitotic shake-off following nocodozole treatment (100 ng/mL for 4 hours).

α-parvin (T-19) - sc-50694 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

α-parvin (T-19): sc-50694. Western blot analysis of α-parvin expression in non-transfected 293T: sc-117752 (A), human α-parvin transfected 293T: sc-176783 (B) and HeLa (C) whole cell lysates.

α-parvin (E-16) - sc-50692 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

α-parvin (N-12) - sc-50693 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

α-parvin (N-12): sc-50693. Western blot analysis of α-parvin expression in A549 (A), U-251-MG (B), NIH/3T3 (C) and MCF7 (D) whole cell lysates.

Anti-Parvin alpha (phospho S8) antibody [EPR2174] - ab79409 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR2174

All lanes : Anti-Parvin alpha (phospho S8) antibody [EPR2174] (ab79409) at 1/5000 dilutionLane 1 : A549 cell lysateLane 2 : A549 cell lysate treated with LPLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Parvin alpha antibody - ab11336 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

ab11336 staining Parvin alpha in the HT1080 cell line from Human fibrosarcoma biopsy by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with ice-cold methanol. Samples were incubated with a CT45 antibody(green) and Parvin alpha antibody (red)(1/50 in PBS + 1% BSA) for 1 hour at 21°C. An Alexa Fluor®594-conjugated Donkey anti-rabbit was used as the secondary antibody.Key: Left Image cells transfected with scrRNA. Right Image cells transfected with CT45 siRNA.

Anti-Parvin alpha antibody - ab102646 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Parvin alpha antibody (ab102646) at 1/100 dilution + Mouse bladder tissue lysates at 35 µg

Anti-Parvin alpha antibody - ab154654 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Parvin alpha antibody (ab154654) at 1/1000 dilution + HeLa whole cell lysate at 20 µg

Anti-Parvin alpha antibody - ab88258 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-Parvin alpha antibody (ab88258) at 1 µg/mlLane 1 : Parvin alpha transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Parvin alpha antibody [1C11] - ab140960 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	1C11

All lanes : Anti-Parvin alpha antibody [1C11] (ab140960) at 1/200 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY Parvin alpha cDNALysates/proteins at 5 µg per lane.

Anti-Parvin alpha antibody [1H2] - ab140502 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H2

Immunofluorescent analysis of COS7 cells transiently transfected with pCMV6-ENTRY Parvin alpha, labelling Parvin alpha with ab140502 at 1/100 dilution.

Anti-Parvin alpha antibody [2B11] - ab139270 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2B11

All lanes : Anti-Parvin alpha antibody [2B11] (ab139270) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Parvin alpha Lysates/proteins at 5 µg per lane.

Anti-Parvin alpha antibody [2G10] - ab139287 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2G10

All lanes : Anti-Parvin alpha antibody [2G10] (ab139287) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY Parvin alpha cDNALysates/proteins at 5 µg per lane.

Anti-Parvin alpha antibody [3C3] - ab156777 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3C3

All lanes : Anti-Parvin alpha antibody [3C3] (ab156777) at 1/200 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY Parvin alpha cDNALysates/proteins at 5 µg per lane.

Anti-Parvin alpha antibody [3H2] - ab156797 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3H2

All lanes : Anti-Parvin alpha antibody [3H2] (ab156797) at 1/200 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Parvin alpha cDNALysates/proteins at 5 µg per lane.

Anti-PARVA Antibody (clone 2G10) - LS-C174641 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2G10

IHC of paraffin-embedded Human Kidney tissue using anti-PARVA mouse monoclonal antibody.

Anti-PARVA Antibody (clone 2F10) - LS-C174632 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2F10

IHC of paraffin-embedded Human pancreas tissue using anti-PARVA mouse monoclonal antibody.

Anti-PARVA Antibody (clone 3C3) - LS-C174629 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3C3

Anti-PARVA Antibody (clone 3H2) - LS-C338025 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3H2

IHC of paraffin-embedded Human pancreas tissue using anti-PARVA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PARVA Antibody (clone 3G9) - LS-C338027 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3G9

Anti-PARVA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PARVA.

Anti-PARVA Antibody (clone 3H9) - LS-C174634 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3H9

Anti-PARVA Antibody (clone 2F9) - LS-C338030 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2F9

IHC of paraffin-embedded Human lymph node tissue using anti-PARVA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PARVA Antibody (clone 2B11) - LS-C338029 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2B11

IHC of paraffin-embedded Human Kidney tissue using anti-PARVA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PARVA Antibody (clone 1H2) - LS-C174628 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H2

IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PARVA mouse monoclonal antibody.

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