| Gene Symbol | PARVA |
|---|---|
| Entrez Gene | 55742 |
| Alt Symbol | CH-ILKBP, MXRA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | parvin, alpha |
| Other Description | actopaxin|alpha-parvin|calponin-like integrin-linked kinase-binding protein|matrix-remodeling-associated protein 2 |
| Swissprots | Q96C85 Q9HA48 Q9NVD7 |
| Accessions | EAW68523 EAW68524 EAW68525 Q9NVD7 AF237771 AAG27173 AF325830 AAK49911 AK001655 BAA91815 AK022316 BAB14009 AK057835 AK098504 AK128814 AK304444 BAH14188 BC014535 AAH14535 BC016713 AAH16713 DC344538 EU832601 ACE87003 HQ448212 ADQ32692 XM_005253015 XP_005253072 NM_018222 NP_060692 |
| Function | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}. |
| Subcellular Location | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton. |
| Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:11722847}. |
| Top Pathways | Focal adhesion |
α-parvin CRISPR/Cas9 KO Plasmid (h) - sc-405769 from Santa Cruz Biotechnology
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α-parvin HDR Plasmid (h) - sc-405769-HDR from Santa Cruz Biotechnology
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α-parvin Double Nickase Plasmid (h) - sc-405769-NIC from Santa Cruz Biotechnology
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α-parvin Double Nickase Plasmid (h2) - sc-405769-NIC-2 from Santa Cruz Biotechnology
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α-parvin CRISPR Activation Plasmid (h) - sc-405769-ACT from Santa Cruz Biotechnology
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α-parvin CRISPR Activation Plasmid (h2) - sc-405769-ACT-2 from Santa Cruz Biotechnology
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α-parvin Lentiviral Activation Particles (h) - sc-405769-LAC from Santa Cruz Biotechnology
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α-parvin Lentiviral Activation Particles (h2) - sc-405769-LAC-2 from Santa Cruz Biotechnology
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α-parvin siRNA (h) - sc-60107 from Santa Cruz Biotechnology
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α-parvin shRNA Plasmid (h) - sc-60107-SH from Santa Cruz Biotechnology
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α-parvin shRNA (h) Lentiviral Particles - sc-60107-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU143471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16356 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16356 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10946 from Sigma-Aldrich
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PARVA siRNA (Human) - CRJ0880 from Cohesion Biosciences
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α-parvin CRISPR/Cas9 KO Plasmid (h2) - sc-405769-KO-2 from Santa Cruz Biotechnology
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α-parvin HDR Plasmid (h2) - sc-405769-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PARVA (NM_018222.4) - SHH370972 from Creative biogene
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PARVA shRNA Plasmid (Human) - CHJ0880 from Cohesion Biosciences
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PARVA miRNA 3'UTR clone - MiUTR3H-09757 from Creative biogene
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