PARVA

Gene Symbol	PARVA
Entrez Gene	55742
Alt Symbol	CH-ILKBP, MXRA2
Species	Human
Gene Type	protein-coding
Description	parvin, alpha
Other Description	actopaxin|alpha-parvin|calponin-like integrin-linked kinase-binding protein|matrix-remodeling-associated protein 2
Swissprots	Q96C85 Q9HA48 Q9NVD7
Accessions	EAW68523 EAW68524 EAW68525 Q9NVD7 AF237771 AAG27173 AF325830 AAK49911 AK001655 BAA91815 AK022316 BAB14009 AK057835 AK098504 AK128814 AK304444 BAH14188 BC014535 AAH14535 BC016713 AAH16713 DC344538 EU832601 ACE87003 HQ448212 ADQ32692 XM_005253015 XP_005253072 NM_018222 NP_060692
Function	Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}.
Subcellular Location	Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
Tissue Specificity	Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:11722847}.
Top Pathways	Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PARVA Gene cDNA Clone - orb144611 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-PARVA-cDNA-Clone - DC04344 from Abgent, a WuXi AppTec company Prices $502.20 Sizes 10 µg Species Human Accession BC016713

PARVA - MBS1268241 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC014535

PARVA - MBS1272753 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016713

Human Actopaxin Gene ORF cDNA clone in cloning vector - HG13919-G from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, C-His tag - HG13919-CH from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13919-NF from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, N-HA tag - HG13919-NY from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13919-NM from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13919-CF from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13919-CM from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid - HG13919-UT from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, C-HA tag - HG13919-CY from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, N-His tag - HG13919-NH from Sino Biological Species Human

Human PARVA ORF clone (NM_018222.4) - CDCL146125 from Creative biogene Species Human

Human PARVA ORF Clone (BC016713) - CDCS414698 from Creative biogene Species Human Accession Q9NVD7

Human PARVA ORF Clone (BC014535) - CDCS414699 from Creative biogene Species Human Accession Q9NVD7

Human PARVA ORF clone (BC016713) - CDCB159545 from Creative biogene Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13919-ACG from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13919-ANG from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13919-ACR from Sino Biological Species Human

Human Actopaxin Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13919-ANR from Sino Biological Species Human

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