| Gene Symbol |
KYNU
|
| Entrez Gene |
8942
|
| Alt Symbol |
KYNUU
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kynureninase
|
| Other Description |
L-kynurenine hydrolase
|
| Swissprots |
B2RCZ5 Q9BVW3 D3DP79 Q6I9T2 Q16719
|
| Accessions |
AAX93159 AAY14727 EAX11599 EAX11600 EAX11601 Q16719 AK223426 BAD97146 AK290900 BAF83589 AK292095 BAF84784 AK315343 BAG37742 AL548658 AW290980 AW296221 BC000879 AAH00879 CB151988 CR457423 CAG33704 HQ447861 ADQ32345 U57721 AAC50650 XM_011512101 XP_011510403 XM_011512102 XP_011510404 XM_011512103 XP_011510405 XM_011512104 XP_011510406 XM_011512105 XP_011510407 XR_923058 NM_001032998 NP_001028170 NM_001199241 NP_001186170 NM_003937 NP_003928
|
| Function |
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}.
|
| Tissue Specificity |
Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.
|
| Top Pathways |
Tryptophan metabolism
|
![Western Blot: KYNU Overexpression Lysate (Adult Normal) [NBL1-12416] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KYNU.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10995_KYNU%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12416-img0002.jpg)