KYNU

Gene Symbol KYNU
Entrez Gene 8942
Alt Symbol KYNUU
Species Human
Gene Type protein-coding
Description kynureninase
Other Description L-kynurenine hydrolase
Swissprots B2RCZ5 Q9BVW3 D3DP79 Q6I9T2 Q16719
Accessions AAX93159 AAY14727 EAX11599 EAX11600 EAX11601 Q16719 AK223426 BAD97146 AK290900 BAF83589 AK292095 BAF84784 AK315343 BAG37742 AL548658 AW290980 AW296221 BC000879 AAH00879 CB151988 CR457423 CAG33704 HQ447861 ADQ32345 U57721 AAC50650 XM_011512101 XP_011510403 XM_011512102 XP_011510404 XM_011512103 XP_011510405 XM_011512104 XP_011510406 XM_011512105 XP_011510407 XR_923058 NM_001032998 NP_001028170 NM_001199241 NP_001186170 NM_003937 NP_003928
Function Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}.
Tissue Specificity Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.
Top Pathways Tryptophan metabolism

kynureninase (E-5) - sc-390360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
kynureninase (E-5): sc-390360. Western blot analysis of kynureninase expression in Hep G2 whole cell lysate (A) and human liver tissue extract (B).

kynureninase (E-14) - sc-132732 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

kynureninase (H-205) - sc-366064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

kynureninase (I-14) - sc-132733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
kynureninase (I-14): sc-132733. Western blot analysis of kynureninase expression in c4 (A) and AMJ2-C8 (B) whole cell lysates and mouse liver tissue extract (C).

Anti-L-Kynurenine Hydrolase antibody - ab56450 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56450 L-Kynurenine Hydrolase antibody at 1ug/ml.

Anti-L-Kynurenine Hydrolase antibody - ab96365 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-L-Kynurenine Hydrolase antibody (ab96365) at 1/1000 dilution + A549 whole cell lysate at 30 µg

Anti-L-Kynurenine Hydrolase antibody - ab172304 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-L-Kynurenine Hydrolase antibody (ab172304) at 1 µg/mlLane 1 : L-Kynurenine Hydrolase transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-L-Kynurenine Hydrolase antibody - C-terminal - ab135786 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-L-Kynurenine Hydrolase antibody - C-terminal (ab135786) at 1/50 dilution + NCI-H460 cell line lysate at 35 µg

Anti-L-Kynurenine Hydrolase antibody - N-terminal - ab166654 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-L-Kynurenine Hydrolase antibody - N-terminal (ab166654) at 1/1000 dilution (at RT for 2 h)Lane 1 : Mouse thymus total cell extractsLane 2 : Human Jurkat total cell extracts

Anti-KYNU Antibody (aa1-465, clone 12K123) - LS-C182896 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K123

Anti-KYNU Antibody (aa2-109) - LS-C308698 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KYNU Antibody - LS-C310866 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KYNU Antibody - LS-C334846 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using KYNU antibody.

Anti-KYNU Antibody (aa1-216, clone 1F1) - LS-C339021 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KYNU (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KYNU.

Anti-KYNU Antibody (N-Terminus) - LS-C80795 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-KYNU Antibody (aa1-216, clone 5E4) - LS-C338992 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E4
IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-KYNU mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-KYNU Antibody (aa1-216, clone 1H1) - LS-C338941 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H1
IHC of paraffin-embedded Human thyroid tissue using anti-KYNU mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-KYNU Antibody (aa251-300) - LS-C80796 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KYNU antibody LS-C80796 IHC of formalin-fixed, paraffin-embedded human Liver. Positive label: Hepatocytes indicated with arrows. Antibody concentration 4-8 ug/ml. Magnification 400X.

Anti-KYNU Antibody (aa114-329) - LS-C186398 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded MCF7 xenograft using KYNU antibody at 1:500 dilution.

Anti-KYNU Antibody (aa359-386) - LS-C165658 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with KYNU Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Kynureninase Antibody - NBP1-56545 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Kynureninase Antibody [NBP1-56545] - Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1 : 312500 Positive control: HepG2 cell lysate KYNU is supported by BioGPS gene expression data to be expressed in HepG2.

Kynureninase Antibody - NBP1-57569 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Kynureninase Antibody [NBP1-57569] - HepG2 cell lysate, concentration 5.0ug/ml.

Kynureninase Antibody (589731) - MAB4887 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 589731
Western blot shows lysates of human liver tissue and A549 human lung carcinoma cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Kynureninase Monoclonal Antibody (Catalog # MAB4887) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Kynureninase at approximately 52 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Kynureninase Antibody - AF4887 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Kynureninase Antibody - NBP2-14180 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KYNU Antibody [NBP2-14180] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-308
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