| Gene Symbol |
CWC22
|
| Entrez Gene |
57703
|
| Alt Symbol |
EIF4GL, NCM, fSAPb
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CWC22 spliceosome-associated protein
|
| Other Description |
CWC22 spliceosome-associated protein homolog|functional spliceosome-associated protein b|nucampholin homolog|pre-mRNA-splicing factor CWC22 homolog
|
| Swissprots |
Q05DC2 Q4G135 Q7Z6I0 Q9H6Q6 Q9HCG8 Q6PEX2 Q9H5L3 Q52LF0
|
| Accessions |
EAX10996 EAX10997 EAX10998 Q9HCG8 AB046824 BAB13430 AK025635 BAB15197 AK026978 BAB15612 AK123647 BC016651 AAH16651 BC031216 AAH31216 BC041662 BC053573 AAH53573 BC057826 AAH57826 BC093952 AAH93952 BC093954 AAH93954 BC143433 BF699499 XM_005246726 XP_005246783 NM_020943 NP_065994
|
| Function |
Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153}.
|
| Subcellular Location |
Nucleus. Nucleus speckle. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins.
|