IL34

Gene Symbol IL34
Entrez Gene 146433
Alt Symbol C16orf77, IL-34
Species Human
Gene Type protein-coding
Description interleukin 34
Other Description interleukin-34
Swissprots B2Z4A8 B2ZC70 B2RC28 Q8N6L2 Q6ZMJ4
Accessions EAW51800 EAW51801 EAW51802 Q6ZMJ4 AK172744 BAD18731 AK307727 AK308799 AK314913 BAG37425 AW292500 BC029804 AAH29804 BQ709387 CD248375 CD515627 EU599219 ACD13474 EU636994 ACD13452 XM_011522902 XP_011521204 XM_011522903 XP_011521205 XM_011522904 XP_011521206 NM_001172771 NP_001166242 NM_001172772 NP_001166243 NM_152456 NP_689669
Function Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
Subcellular Location Secreted {ECO:0000269|PubMed:18467591}.
Tissue Specificity Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. {ECO:0000269|PubMed:18467591}.

IL-34 (H-222) - sc-135176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-34 (H-222): sc-135176. Western blot analysis of IL-34 expression in SK-N-MC whole cell lysate.

IL-34 (T-16) - sc-243071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-34 (C-19) - sc-243072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-34 (C-19): sc-243072. Western blot analysis of IL-34 expression in mouse spleen tissue extract.

Anti-Interleukin 34 antibody - ab75723 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Interleukin 34 antibody (ab75723) at 1 µg/mlLane 1 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLane 2 : PC3 (human prostate carcinoma cell line) Whole cell lysate Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) (ab65484) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Interleukin 34 antibody - ab74548 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Interleukin 34 antibody (ab74548) at 0.25 µg/mlLane 1 : Human brain tissue lysate, minus immunising peptideLane 2 : Human brain tissue lysate, plus immmunising peptideLysates/proteins at 15 µg per lane.

Anti-Interleukin 34 antibody - ab111978 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Interleukin 34 antibody (ab111978) at 1/500 dilution + Human fetal brain lysate

Anti-Interleukin 34 antibody [1D12] - ab101443 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D12
Anti-Interleukin 34 antibody [1D12] (ab101443) at 1/500 dilution + Interleukin 34-hIgGFc transfected HEK293 cell lysate

Anti-Interleukin 34 antibody - N-terminal - ab174125 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Interleukin 34 antibody - N-terminal (ab174125) at 1/100 dilution + NCI-H292 cell line lysate at 35 µgdeveloped using the ECL technique

Anti-IL34 Antibody - LS-C125825 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-IL34 Antibody - LS-C125824 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-IL34 Antibody (Biotin) - LS-C130291 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-IL34 Antibody (Biotin) - LS-C143810 from LifeSpan Bioscience

Prices $650.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-IL34 Antibody - LS-C143811 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-IL34 Antibody (aa27-53, AP) - LS-C236592 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa27-53, APC) - LS-C236591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa27-53, Biotin) - LS-C236593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (N-Terminus) - LS-C83914 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of IL-34 in human brain tissue lysate with IL-34 antibody at 0.25 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Anti-IL34 Antibody (aa27-53, FITC) - LS-C236594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa27-53, PE) - LS-C236597 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa27-53, Azide-free, HRP) - LS-C249270 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa21-234, Biotin) - LS-C297196 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa21-235, Biotin) - LS-C297855 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa21-235, FITC) - LS-C303430 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (aa21-234, FITC) - LS-C304628 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL34 Antibody (N-Terminus) - LS-C170480 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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