IL34

Gene Symbol	IL34
Entrez Gene	146433
Alt Symbol	C16orf77, IL-34
Species	Human
Gene Type	protein-coding
Description	interleukin 34
Other Description	interleukin-34
Swissprots	B2Z4A8 B2ZC70 B2RC28 Q8N6L2 Q6ZMJ4
Accessions	EAW51800 EAW51801 EAW51802 Q6ZMJ4 AK172744 BAD18731 AK307727 AK308799 AK314913 BAG37425 AW292500 BC029804 AAH29804 BQ709387 CD248375 CD515627 EU599219 ACD13474 EU636994 ACD13452 XM_011522902 XP_011521204 XM_011522903 XP_011521205 XM_011522904 XP_011521206 NM_001172771 NP_001166242 NM_001172772 NP_001166243 NM_152456 NP_689669
Function	Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
Subcellular Location	Secreted {ECO:0000269|PubMed:18467591}.
Tissue Specificity	Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. {ECO:0000269|PubMed:18467591}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Interleukin 34 full length protein - ab109933 from Abcam Category Protein Source HEK 293 cells Species Human

Human Interleukin 34 full length protein - ab140559 from Abcam Category Protein Source E. coli Species Human

Human Interleukin 34 full length protein - ab194166 from Abcam Category Protein Source Mammalian Species Human

Human Interleukin 34 full length protein - ab195091 from Abcam Category Protein Source Mammalian Species Human

Interleukin 34 peptide - ab94831 from Abcam Category Peptide

Mouse Interleukin 34 full length protein - ab202163 from Abcam Category Protein Source E. coli Species Mouse

Mouse Interleukin 34 full length protein - ab184584 from Abcam Category Protein Source Yeast Species Mouse

IL34 Antibody Blocking Peptide - LS-E5908 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL34 Antibody Blocking Peptide - LS-E30562 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IL34 Antibody Blocking Peptide - LS-E30563 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IL34 Antibody Blocking Peptide - LS-E24563 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Human IL-34 Biologically Active Protein - NBP2-36595 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,599.00 Sizes 2 µg, 10 µg, 1 mg Source Mouse myeloma cell line, NS0 Species Human

Human IL-34 Biologically Active Protein - NBP2-36504 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 2 µg, 10 µg Source Mouse myeloma cell line, NS0-derived Species Human

Human IL-34 Biologically Active Protein - NBP2-36519 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 2 µg, 10 µg Source Mouse myeloma cell line, NS0-derived Species Human

Interleukin 34 Blocking Peptide - NBP1-76357PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human Interleukin 34 Protein - NBP2-22659 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Species Human

Interleukin 34 Blocking Peptide - NBP1-76356PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IL34-Antibody-N-term-Blocking-Peptide - BP18473a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL34 recombinant protein - GTX53809 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source HEK293 cells

Recombinant Human IL-34 - 5265-IL-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asn21-Pro242, with a C-terminal 6-His tag

Recombinant Human IL-34, CF - 5265-IL-010/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asn21-Pro242, with a C-terminal 6-His tag

Human IL34 protein - orb168596 from Biorbyt Category Protein Prices $187.00, $323.00 Sizes 2 μg, 10 μg Species Human

IL34 protein (His tag) - 80R-2694 from Fitzgerald Category Protein Prices $270.00 Sizes 50 µg Source E.coli

Interleukin-34 / IL34 - AR20023PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source HEK293 cells Species Human

Interleukin-34 / IL34 - AR20023PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source HEK293 cells Species Human

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