| Gene Symbol |
IL34
|
| Entrez Gene |
146433
|
| Alt Symbol |
C16orf77, IL-34
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 34
|
| Other Description |
interleukin-34
|
| Swissprots |
B2Z4A8 B2ZC70 B2RC28 Q8N6L2 Q6ZMJ4
|
| Accessions |
EAW51800 EAW51801 EAW51802 Q6ZMJ4 AK172744 BAD18731 AK307727 AK308799 AK314913 BAG37425 AW292500 BC029804 AAH29804 BQ709387 CD248375 CD515627 EU599219 ACD13474 EU636994 ACD13452 XM_011522902 XP_011521204 XM_011522903 XP_011521205 XM_011522904 XP_011521206 NM_001172771 NP_001166242 NM_001172772 NP_001166243 NM_152456 NP_689669
|
| Function |
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:18467591}.
|
| Tissue Specificity |
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. {ECO:0000269|PubMed:18467591}.
|
![Western Blot: Interleukin 34 Overexpression Lysate (Adult Normal) [NBL1-11955] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Interleukin 34.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1040_Interleukin%252034%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11955-img0002.jpg)