Gene Symbol | ZKSCAN3 |
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Entrez Gene | 80317 |
Alt Symbol | ZF47, ZFP306, ZNF306, ZNF309, ZSCAN13, ZSCAN35, Zfp47, dJ874C20.1, dJ874C20.1., zfp-47 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger with KRAB and SCAN domains 3 |
Other Description | zinc finger and SCAN domain-containing protein 13|zinc finger protein 306|zinc finger protein 309|zinc finger protein 47 homolog|zinc finger protein with KRAB and SCAN domains 3|zinc finger protein zfp47 |
Swissprots | H7BXX1 B3KVC0 Q5VXH3 Q9H4T3 Q92972 B2R8W2 Q9BRR0 |
Accessions | EAX03157 EAX03158 Q9BRR0 AK091225 BAG52311 AK122790 BAG53732 AK313532 BAG36309 BC006118 AAH06118 BM762243 BT007427 AAP36095 DA440043 DB214839 DN831452 U71601 AAB16813 XM_005249423 XP_005249480 XM_006715215 XP_006715278 XM_006715216 XP_006715279 XM_006715218 XP_006715281 XM_006715219 XP_006715282 NM_001242894 NP_001229823 NM_001242895 NP_001229824 NM_024493 NP_077819 |
Function | Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function. |
ZKSCAN3 (K-13) - sc-132887 from Santa Cruz Biotechnology
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ZKSCAN3 (H-50) - sc-382194 from Santa Cruz Biotechnology
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ZKSCAN3 (N-13) - sc-132889 from Santa Cruz Biotechnology
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ZKSCAN3 (B-24) - sc-102175 from Santa Cruz Biotechnology
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Anti-ZKSCAN3 antibody - ab96731 from Abcam
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Anti-ZKSCAN3 antibody - ab187866 from Abcam
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Anti-ZKSCAN3 antibody - ab89170 from Abcam
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Anti-ZKSCAN3 antibody - ab111490 from Abcam
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Anti-ZKSCAN3 antibody - ab26142 from Abcam
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Anti-ZKSCAN3 / ZNF306 Antibody (clone 2A5) - LS-C139433 from LifeSpan Bioscience
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Anti-ZKSCAN3 / ZNF306 Antibody (N-Terminus) - LS-C29809 from LifeSpan Bioscience
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Anti-ZKSCAN3 / ZNF306 Antibody (aa175-440) - LS-C178598 from LifeSpan Bioscience
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Anti-ZKSCAN3 / ZNF306 Antibody (aa1-394) - LS-C185760 from LifeSpan Bioscience
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ZKSCAN3 Antibody - NBP1-31566 from Novus Biologicals
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ZKSCAN3 Antibody - H00080317-B01 from Novus Biologicals
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ZKSCAN3 Antibody (2A5) - H00080317-M16 from Novus Biologicals
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ZKSCAN3 Antibody (2A1) - H00080317-M09 from Novus Biologicals
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ZKSCAN3 Antibody - H00080317-B01P-50ug from Novus Biologicals
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ZKSCAN3 Antibody - H00080317-A01 from Novus Biologicals
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Anti-ZKSCAN3 antibody produced in rabbit - HPA009637 from Sigma-Aldrich
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Anti-ZNF306 antibody produced in rabbit - AV33609 from Sigma-Aldrich
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Anti-ZKSCAN3 antibody produced in rabbit - SAB2700902 from Sigma-Aldrich
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ANTI-ZKSCAN3 antibody produced in mouse - SAB1411932 from Sigma-Aldrich
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ZNF306 antibody - N-terminal region (ARP33609_P050) - ARP33609_P050 from Aviva Systems Biology
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ZNF306 antibody - orb73751 from Biorbyt
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