| Gene Symbol |
ZKSCAN3
|
| Entrez Gene |
80317
|
| Alt Symbol |
ZF47, ZFP306, ZNF306, ZNF309, ZSCAN13, ZSCAN35, Zfp47, dJ874C20.1, dJ874C20.1., zfp-47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger with KRAB and SCAN domains 3
|
| Other Description |
zinc finger and SCAN domain-containing protein 13|zinc finger protein 306|zinc finger protein 309|zinc finger protein 47 homolog|zinc finger protein with KRAB and SCAN domains 3|zinc finger protein zfp47
|
| Swissprots |
H7BXX1 B3KVC0 Q5VXH3 Q9H4T3 Q92972 B2R8W2 Q9BRR0
|
| Accessions |
EAX03157 EAX03158 Q9BRR0 AK091225 BAG52311 AK122790 BAG53732 AK313532 BAG36309 BC006118 AAH06118 BM762243 BT007427 AAP36095 DA440043 DB214839 DN831452 U71601 AAB16813 XM_005249423 XP_005249480 XM_006715215 XP_006715278 XM_006715216 XP_006715279 XM_006715218 XP_006715281 XM_006715219 XP_006715282 NM_001242894 NP_001229823 NM_001242895 NP_001229824 NM_024493 NP_077819
|
| Function |
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
|