Gene Symbol | ZKSCAN3 |
---|---|
Entrez Gene | 80317 |
Alt Symbol | ZF47, ZFP306, ZNF306, ZNF309, ZSCAN13, ZSCAN35, Zfp47, dJ874C20.1, dJ874C20.1., zfp-47 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger with KRAB and SCAN domains 3 |
Other Description | zinc finger and SCAN domain-containing protein 13|zinc finger protein 306|zinc finger protein 309|zinc finger protein 47 homolog|zinc finger protein with KRAB and SCAN domains 3|zinc finger protein zfp47 |
Swissprots | H7BXX1 B3KVC0 Q5VXH3 Q9H4T3 Q92972 B2R8W2 Q9BRR0 |
Accessions | EAX03157 EAX03158 Q9BRR0 AK091225 BAG52311 AK122790 BAG53732 AK313532 BAG36309 BC006118 AAH06118 BM762243 BT007427 AAP36095 DA440043 DB214839 DN831452 U71601 AAB16813 XM_005249423 XP_005249480 XM_006715215 XP_006715278 XM_006715216 XP_006715279 XM_006715218 XP_006715281 XM_006715219 XP_006715282 NM_001242894 NP_001229823 NM_001242895 NP_001229824 NM_024493 NP_077819 |
Function | Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function. |
Human ZKSCAN3 protein fragment - ab127276 from Abcam
|
||||||||||
ZKSCAN3 / ZNF306 Antibody Blocking Peptide - LS-E11884 from LifeSpan Bioscience
|
||||||||||
Recombinant Human ZKSCAN3 Protein - H00080317-Q01 from Novus Biologicals
|
||||||||||
Recombinant Human ZKSCAN3 Protein - H00080317-P01 from Novus Biologicals
|
||||||||||
Recombinant Human ZKSCAN3 Protein - H00080317-P02 from Novus Biologicals
|
||||||||||
ZNF306 - H00080317-P01-10 from Acris Antibodies
|
||||||||||
ZNF306 - H00080317-P01-25 from Acris Antibodies
|
||||||||||
ZNF306 - H00080317-P02 from Acris Antibodies
|
||||||||||
ZNF306 - H00080317-P02-10 from Acris Antibodies
|
||||||||||
ZNF306 - H00080317-P02-25 from Acris Antibodies
|
||||||||||
ZNF306 - H00080317-Q01-10 from Acris Antibodies
|
||||||||||
ZNF306 - H00080317-Q01-25 from Acris Antibodies
|
||||||||||
ZKSCAN3 fusion protein - ag14785 from Proteintech Group
|
||||||||||
ZKSCAN3 fusion protein - Ag14715 from Proteintech Group
|
||||||||||
Recombinant Human Zinc finger protein with KRAB and SCAN domains 3(ZKSCAN3) - CSB-YP861122HU CSB-EP861122HU CSB-BP861122HU CSB-MP861122HU from Cusabio
|
||||||||||
ZNF306 - TP302971 from Acris Antibodies
|
||||||||||
Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) , Recombinant Protein - MBS1476171 from MyBioSource
|
||||||||||
ZKSCAN3 Recombinant Protein Antigen - NBP2-47570PEP from Novus Biologicals
|
||||||||||
ZKSCAN3-Blocking-Peptide-N-Term - BP21797a from Abgent, a WuXi AppTec company
|
||||||||||
ZKSCAN3 Peptide, Human - M34GP17839H from Creative Peptides
|