Gene Symbol | ZKSCAN3 |
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Entrez Gene | 80317 |
Alt Symbol | ZF47, ZFP306, ZNF306, ZNF309, ZSCAN13, ZSCAN35, Zfp47, dJ874C20.1, dJ874C20.1., zfp-47 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger with KRAB and SCAN domains 3 |
Other Description | zinc finger and SCAN domain-containing protein 13|zinc finger protein 306|zinc finger protein 309|zinc finger protein 47 homolog|zinc finger protein with KRAB and SCAN domains 3|zinc finger protein zfp47 |
Swissprots | H7BXX1 B3KVC0 Q5VXH3 Q9H4T3 Q92972 B2R8W2 Q9BRR0 |
Accessions | EAX03157 EAX03158 Q9BRR0 AK091225 BAG52311 AK122790 BAG53732 AK313532 BAG36309 BC006118 AAH06118 BM762243 BT007427 AAP36095 DA440043 DB214839 DN831452 U71601 AAB16813 XM_005249423 XP_005249480 XM_006715215 XP_006715278 XM_006715216 XP_006715279 XM_006715218 XP_006715281 XM_006715219 XP_006715282 NM_001242894 NP_001229823 NM_001242895 NP_001229824 NM_024493 NP_077819 |
Function | Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function. |
ZKSCAN3 CRISPR/Cas9 KO Plasmid (h) - sc-416370 from Santa Cruz Biotechnology
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ZKSCAN3 HDR Plasmid (h) - sc-416370-HDR from Santa Cruz Biotechnology
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ZKSCAN3 Double Nickase Plasmid (h) - sc-416370-NIC from Santa Cruz Biotechnology
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ZKSCAN3 Double Nickase Plasmid (h2) - sc-416370-NIC-2 from Santa Cruz Biotechnology
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ZKSCAN3 CRISPR Activation Plasmid (h) - sc-416370-ACT from Santa Cruz Biotechnology
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ZKSCAN3 CRISPR Activation Plasmid (h2) - sc-416370-ACT-2 from Santa Cruz Biotechnology
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ZKSCAN3 Lentiviral Activation Particles (h) - sc-416370-LAC from Santa Cruz Biotechnology
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ZKSCAN3 Lentiviral Activation Particles (h2) - sc-416370-LAC-2 from Santa Cruz Biotechnology
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ZKSCAN3 siRNA (h) - sc-95093 from Santa Cruz Biotechnology
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ZKSCAN3 shRNA Plasmid (h) - sc-95093-SH from Santa Cruz Biotechnology
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ZKSCAN3 shRNA (h) Lentiviral Particles - sc-95093-V from Santa Cruz Biotechnology
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ZKSCAN3 RNAi - H00080317-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN23228 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23228 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04754 from Sigma-Aldrich
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ZKSCAN3 siRNA (Human) - CRJ2851 from Cohesion Biosciences
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ZKSCAN3 - MBS8235159 from MyBioSource
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shRNA set against Human ZKSCAN3 (NM_024493.3) - SHH452756 from Creative biogene
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Human ZKSCAN3 siRNA - orb273352 from Biorbyt
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Mouse ZKSCAN3 siRNA - orb288346 from Biorbyt
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ZKSCAN3 shRNA Plasmid (Human) - CHJ2851 from Cohesion Biosciences
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ZKSCAN3 miRNA 3'UTR clone - MiUTR3H-12600 from Creative biogene
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