UBE2C

Gene Symbol	UBE2C
Entrez Gene	11065
Alt Symbol	UBCH10, dJ447F3.2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2C
Other Description	cyclin-selective ubiquitin carrier protein|mitotic-specific ubiquitin-conjugating enzyme|ubiquitin-conjugating enzyme E2 C|ubiquitin-protein ligase C
Swissprots	O00762 E1P5N7 A6NP33 G3XAB7
Accessions	EAW75804 EAW75805 EAW75806 EAW75807 EAW75808 EAW75809 O00762 AK311949 BAG34890 BC007656 AAH07656 BC016292 AAH16292 BC028161 BC032677 BC050736 AAH50736 BF974975 BI858659 BM556795 BM747513 BP227692 BT007300 AAP35964 BT007515 AAP36183 BT020165 AAV38967 BT020166 AAV38968 BU169315 BU171488 BU844974 CB143441 CK904708 CN354813 CN354815 CR456988 CAG33269 DB062573 DQ892416 ABM83342 DQ895630 ABM86556 EU831629 ACE87229 EU831714 ACE86548 U73379 AAB53362 NM_001281741 NP_001268670 NM_001281742 NP_001268671 NM_007019 NP_008950 NM_181799 NP_861515 NM_181800 NP_861516 NM_181801 NP_861517 NR_104036 NR_104037 NM_181802 NM_181803
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE2C full length protein - ab151891 from Abcam Category Protein Source E. coli Species Human

Human UBE2C full length protein - ab157063 from Abcam Category Protein Source E. coli Species Human

Human UBE2C full length protein - ab131664 from Abcam Category Protein Source E. coli Species Human

Human UBE2C full length protein - ab59311 from Abcam Category Protein Source E. coli Species Human

Human UBE2C peptide - ab22967 from Abcam Category Peptide Species Human

UBE2C protein (Human) - ab127404 from Abcam Category Protein Source E. coli Species Human

UBCH10 / UBE2C Antibody Blocking Peptide - LS-E15998 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBCH10 / UBE2C Antibody Blocking Peptide - LS-E25405 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBCH10 / UBE2C Antibody Blocking Peptide - LS-E15863 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBCH10 / UBE2C Antibody Blocking Peptide - LS-E15862 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBCH10 / UBE2C Antibody Blocking Peptide - LS-E6865 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBCH10 / UBE2C Antibody Blocking Peptide - LS-E6866 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UbcH10/UBE2C His (N-Term) Protein - NBP2-35090 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,969.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

UbcH10/UBE2C Recombinant Protein - H00011065-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UbcH10/UBE2C Partial Recombinant Protein - H00011065-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UbcH10/UBE2C Recombinant Protein - H00011065-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UbcH10/UBE2C Partial Recombinant Protein - H00011065-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UbcH10/UBE2C Protein - NBP2-22923 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human UbcH10/UBE2C Protein - NBP1-99191 from Novus Biologicals Category Protein Prices $145.00 Sizes 10 µg Source E. coli Species Human

UbcH10/UBE2C Protein - NBP1-99630 from Novus Biologicals Category Protein Species Human

UBE2C-Antibody-N-term-G25-Blocking-Peptide - BP2119d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2C-Antibody-C-term-Blocking-Peptide - BP2119b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2C-Antibody-N-term-Blocking-Peptide - BP2119a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2C blocking peptide - GTX89866-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human His6-UbcH10/UBE2C, CF - E2-650-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal Met and 7-His tag

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