UBE2C
| Gene Symbol | UBE2C |
|---|---|
| Entrez Gene | 11065 |
| Alt Symbol | UBCH10, dJ447F3.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2C |
| Other Description | cyclin-selective ubiquitin carrier protein|mitotic-specific ubiquitin-conjugating enzyme|ubiquitin-conjugating enzyme E2 C|ubiquitin-protein ligase C |
| Swissprots | O00762 E1P5N7 A6NP33 G3XAB7 |
| Accessions | EAW75804 EAW75805 EAW75806 EAW75807 EAW75808 EAW75809 O00762 AK311949 BAG34890 BC007656 AAH07656 BC016292 AAH16292 BC028161 BC032677 BC050736 AAH50736 BF974975 BI858659 BM556795 BM747513 BP227692 BT007300 AAP35964 BT007515 AAP36183 BT020165 AAV38967 BT020166 AAV38968 BU169315 BU171488 BU844974 CB143441 CK904708 CN354813 CN354815 CR456988 CAG33269 DB062573 DQ892416 ABM83342 DQ895630 ABM86556 EU831629 ACE87229 EU831714 ACE86548 U73379 AAB53362 NM_001281741 NP_001268670 NM_001281742 NP_001268671 NM_007019 NP_008950 NM_181799 NP_861515 NM_181800 NP_861516 NM_181801 NP_861517 NR_104036 NR_104037 NM_181802 NM_181803 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386}. |
| Top Pathways | Ubiquitin mediated proteolysis |
UBE2C CRISPR/Cas9 KO Plasmid (h) - sc-402962 from Santa Cruz Biotechnology
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UBE2C HDR Plasmid (h) - sc-402962-HDR from Santa Cruz Biotechnology
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UBE2C Double Nickase Plasmid (h) - sc-402962-NIC from Santa Cruz Biotechnology
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UBE2C Double Nickase Plasmid (h2) - sc-402962-NIC-2 from Santa Cruz Biotechnology
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UBE2C CRISPR Activation Plasmid (h) - sc-402962-ACT from Santa Cruz Biotechnology
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UBE2C CRISPR Activation Plasmid (h2) - sc-402962-ACT-2 from Santa Cruz Biotechnology
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UBE2C Lentiviral Activation Particles (h) - sc-402962-LAC from Santa Cruz Biotechnology
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UBE2C Lentiviral Activation Particles (h2) - sc-402962-LAC-2 from Santa Cruz Biotechnology
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UBE2C siRNA (h) - sc-61742 from Santa Cruz Biotechnology
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UBE2C shRNA Plasmid (h) - sc-61742-SH from Santa Cruz Biotechnology
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UBE2C shRNA (h) Lentiviral Particles - sc-61742-V from Santa Cruz Biotechnology
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UbcH10/UBE2C RNAi - H00011065-R03 from Novus Biologicals
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UbcH10/UBE2C RNAi - H00011065-R02 from Novus Biologicals
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UbcH10/UBE2C RNAi - H00011065-R05 from Novus Biologicals
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UbcH10/UBE2C RNAi - H00011065-R04 from Novus Biologicals
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UbcH10/UBE2C RNAi - H00011065-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22354 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22354 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01200 from Sigma-Aldrich
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UBE2C siRNA (Human) - CRH7563 from Cohesion Biosciences
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UbcH10/UBE2C RNAi - H00011065-R06 from Novus Biologicals
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UBE2C - MBS8210164 from MyBioSource
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shRNA set against Human UBE2C (NM_181803.1) - SHH438856 from Creative biogene
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shRNA set against Human UBE2C(NM_007019.2) - SHL110298 from Creative biogene
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