UBE2C

Gene Symbol UBE2C
Entrez Gene 11065
Alt Symbol UBCH10, dJ447F3.2
Species Human
Gene Type protein-coding
Description ubiquitin-conjugating enzyme E2C
Other Description cyclin-selective ubiquitin carrier protein|mitotic-specific ubiquitin-conjugating enzyme|ubiquitin-conjugating enzyme E2 C|ubiquitin-protein ligase C
Swissprots O00762 E1P5N7 A6NP33 G3XAB7
Accessions EAW75804 EAW75805 EAW75806 EAW75807 EAW75808 EAW75809 O00762 AK311949 BAG34890 BC007656 AAH07656 BC016292 AAH16292 BC028161 BC032677 BC050736 AAH50736 BF974975 BI858659 BM556795 BM747513 BP227692 BT007300 AAP35964 BT007515 AAP36183 BT020165 AAV38967 BT020166 AAV38968 BU169315 BU171488 BU844974 CB143441 CK904708 CN354813 CN354815 CR456988 CAG33269 DB062573 DQ892416 ABM83342 DQ895630 ABM86556 EU831629 ACE87229 EU831714 ACE86548 U73379 AAB53362 NM_001281741 NP_001268670 NM_001281742 NP_001268671 NM_007019 NP_008950 NM_181799 NP_861515 NM_181800 NP_861516 NM_181801 NP_861517 NR_104036 NR_104037 NM_181802 NM_181803
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386}.
Top Pathways Ubiquitin mediated proteolysis

UBE2C Antibody - 14234 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using UBE2C Antibody (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower).

UBE2C (B-8) - sc-271050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE2C (B-8): sc-271050. Western blot analysis of UBE2C expression in non-transfected: sc-117752 (A) and human UBE2C transfected: sc-116349 (B) 293T whole cell lysates.

UBE2C (C-12) - sc-47543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UBE2C (B-4) - sc-166499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE2C (B-4): sc-166499. Western blot analysis of UBE2C expression in non-transfected: sc-117752 (A) and human UBE2C transfected: sc-116349 (B) 293T whole cell lysates.

UBE2C (H-90) - sc-99146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
UBE2C (H-90): sc-99146. Western blot analysis of UBE2C expression in non-transfected: sc-110760 (A) and human UBE2C transfected: sc-111903 (B) 293 whole cell lysates.

UBE2C (N-13) - sc-47545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE2C (N-13): sc-47545. Western blot analysis of UBE2C expression in HeLa (A) and SW480 (B) whole cell lysates.

UBE2C (B-12) - sc-166339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE2C (B-12): sc-166339. Western blot analysis of UBE2C expression in non-transfected: sc-117752 (A) and human UBE2C transfected: sc-116349 (B) 293T whole cell lysates.

Anti-UBE2C antibody - ab12290 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Image courtesy of Human Protein Atlas ab12290 stainning UBEC2 in the nucleus of surface epithelial cells of human esophagus. Paraffin-embbeded tissue was incubated with ab12290 (1/75 dilution) for 30 minutes at room temperature. Antigen retrieval was performed by heat induction in citrate buffer pH 6.ab12290 was tested in a tissue microarray (TMA) containing a wide range of normal and cancer tissues as well as a cell microarray consisting of a range of commonly used, well characterised human cell lines. Further results for this antibody can be found at www.proteinatlas.org

Anti-UBE2C antibody - ab187181 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UBE2C antibody (ab187181) at 1/500 dilutionLane 1 : 22RV1 cell extractLane 2 : THP1 cell extractLane 3 : U87 cell extractLane 4 : SW620 cell extractLane 5 : SK-OV-3 cell extract

Anti-UBE2C antibody - ab3935 from Abcam

Prices $385.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UBE2C antibody - ab56861 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
UBE2C antibody (ab56861) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-UBE2C antibody [EPR5161(2)] - ab125002 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5161(2)
All lanes : Anti-UBE2C antibody [EPR5161(2)] (ab125002) at 1/1000 dilutionLane 1 : SW480 cell lysateLane 2 : HeLa cell lysateLane 3 : MCF7 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-UBCH10 / UBE2C Antibody (aa167-179) - LS-C55643 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (N-Terminus, AP) - LS-C218236 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (Internal, clone EPR5161(2)) - LS-C138994 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5161(2)
Western blot analysis on (A) SW480, (B) HeLa, (C) MCF-7, and (D) 293T cell lysates using anti-UBE2C / UBCH10 antibody.

Anti-UBCH10 / UBE2C Antibody (N-Terminus, APC) - LS-C218237 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (aa110-159) - LS-C80545 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-UBCH10 / UBE2C Antibody (aa38-87) - LS-C80544 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-UBCH10 / UBE2C Antibody (N-Terminus, Biotin) - LS-C218238 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (N-Terminus, FITC) - LS-C218239 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (N-Terminus, Azide-free, HRP) - LS-C218240 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (aa71-120) - LS-C116236 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UBE2C antibody LS-C116236 Western blot of THP-1 cell lysate.

Anti-UBCH10 / UBE2C Antibody (C-Terminus, APC) - LS-C221000 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (N-Terminus, PE) - LS-C218241 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBCH10 / UBE2C Antibody (C-Terminus, AP) - LS-C220999 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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