Gene Symbol | MMP12 |
---|---|
Entrez Gene | 4321 |
Alt Symbol | HME, ME, MME, MMP-12 |
Species | Human |
Gene Type | protein-coding |
Description | matrix metallopeptidase 12 |
Other Description | macrophage metalloelastase|matrix metallopeptidase 12 (macrophage elastase)|matrix metalloproteinase 12 (macrophage elastase) |
Swissprots | B7ZLF6 B2R9X8 Q2M1L9 P39900 |
Accessions | AAB06314 AAB36943 AAW29944 EAW67033 P39900 AI343504 AI352562 AK313959 BAG36675 AW172994 BC112301 AAI12302 BC143773 AAI43774 BE440047 BE813419 HQ258263 ADR83017 L23808 AAA58658 NM_002426 NP_002417 |
Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000305}. |
Tissue Specificity | Found in alveolar macrophages but not in peripheral blood monocytes. |