| Gene Symbol | DGKE |
|---|---|
| Entrez Gene | 8526 |
| Alt Symbol | DAGK5, DAGK6, DGK, NPHS7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | diacylglycerol kinase, epsilon 64kDa |
| Other Description | DAG kinase epsilon|DGK-epsilon|diacylglycerol kinase epsilon|diglyceride kinase epsilon |
| Swissprots | P52429 Q8TBM4 Q9UKQ3 |
| Accessions | AAD45666 EAW94526 P52429 AB209365 BAD92602 AK057591 AK129803 AK293039 BAF85728 AK310668 AL555194 BC022297 AAH22297 BC130629 AAI30630 BC130631 AAI30632 BM682264 DB221284 HQ258315 ADR83069 U49379 AAC50497 XM_011525394 XP_011523696 XM_011525395 XP_011523697 XM_011525396 XP_011523698 XM_011525397 XP_011523699 XM_011525398 XP_011523700 XR_934581 NM_003647 NP_003638 |
| Function | Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:23542698}. Cytoplasm {ECO:0000269|PubMed:23542698}. |
| Tissue Specificity | Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level). {ECO:0000269|PubMed:23542698}. |
| Top Pathways | Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system |