CIR1

Gene Symbol CIR1
Entrez Gene 9541
Alt Symbol CIR
Species Human
Gene Type protein-coding
Description corepressor interacting with RBPJ, 1
Other Description CBF1 interacting corepressor|CBF1-interacting corepressor|corepressor interacting with RBPJ 1|recepin
Swissprots A8K8M4 Q8IWI2 Q86X95 Q4G1B9 Q12804 A6NFI6 Q6PJI4 O95367
Accessions AAY24216 EAX11144 EAX11145 EAX11146 Q86X95 AF098297 AAD05243 AK292389 BAF85078 BC015040 BC021175 AAH21175 BC031018 AAH31018 BC038987 AAH38987 BC046098 AAH46098 BU596189 U03644 AAA17853 NM_199075 NM_004882 NP_004873
Function May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.
Subcellular Location Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Tissue Specificity Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:9874765}.
Top Pathways Notch signaling pathway

CIR (H-1) - sc-514120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIR (H-1): sc-514120. Western blot analysis of CIR expression in HeLa nuclear extract (A) and K-562 (B), Hep G2 (C) and Jurkat (D) whole cell lysates.

CIR (A-20) - sc-9470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CIR (A-20): sc-9470. Western blot analysis of CIR expression in K-562 (A) and HEK293 (B) whole cell lysates.

CIR (C-19) - sc-9471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CIR (C-19): sc-9471. Western blot analysis of CIR expression in K-562 (A) and HEK293 (B) whole cell lysates.

CIR (H-160) - sc-367078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CIR (H-160): sc-367078. Western blot analysis of CIR expression in HeLa nuclear extract.

CIR (L-22) - sc-130722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CIR (L-22): sc-130722. Western blot analysis of CIR expression in K-562 whole cell lysate.

Anti-CBF1 interacting corepressor antibody - ab113203 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CBF1 interacting corepressor antibody (ab113203) at 0.1 µg/mlLane 1 : HeLa cell Lysate at 50 µgLane 2 : HeLa cell Lysate at 15 µgLane 3 : Jurkat cell Lysate at 50 µgLane 4 : 293T cell Lysate at 50 µg

Anti-CBF1 interacting corepressor antibody - ab50830 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CBF1 interacting corepressor antibody (ab50830) at 0.25 µg/mlLane 1 : MW ladderLane 2 : Transfected 293T cell lysateSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CIR1 Antibody (C-Terminus) - LS-C30239 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Transfected 293T Cell Lysate

Anti-CIR1 Antibody (aa136-204) - LS-C306962 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CIR1 Antibody (aa177-226) - LS-C80072 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-CIR1 Antibody (aa187-236) - LS-C187135 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Pancreas Tumor. CIR1 antibody dilution 1.0 ug/ml.

Anti-CIR1 Antibody (aa400-450) - LS-C289840 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human CIR1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), Jurkat (J; 50 ug) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-CIR1 antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. CIR1 was also immunoprecipitated by rabbit anti-CIR1 antibody BL11114, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 seconds (B).

CBF1-interacting corepressor Antibody - NBP1-88083 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CBF1-interacting corepressor Antibody [NBP1-88083] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4

CBF1-interacting corepressor Antibody - H00009541-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: CBF1-interacting corepressor Antibody [H00009541-A01] - Western Blot analysis of CIR expression in HeLa ( Cat # L013V1 ).

CBF1-interacting corepressor Antibody - NBP1-71896 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CBF1-interacting corepressor Antibody [NBP1-71896] - Whole cell lysate from HeLa (15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), Jurkat (J; 50 mcg) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-CIR1 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. CIR1 was also immunoprecipitated by another rabbit anti-CIR1 antibody which recognizes an upstream epitope.

CBF1-interacting corepressor Antibody (2E11) - H00009541-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E11
Western Blot: CBF1-interacting corepressor Antibody (2E11) [H00009541-M01] - CIR monoclonal antibody (M01), clone 2E11. Analysis of CIR expression in HeLa.

Anti-CIR (AB2) antibody produced in rabbit - AV33737 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal muscle (<B>Cat. No. AV33737</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type fetal muscle

Anti-CIR1 antibody produced in rabbit - HPA015784 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AC106900.1: <B>Cat. No. HPA015784</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human fallopian tube shows strong nuclear positivity in glandular cells.

Monoclonal Anti-CIR antibody produced in mouse - SAB1402475 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E11
<B>Immunoblotting</B><BR/>Monoclonal Anti-CIR, antibody produced in mouse, clone 2E11, purified immunoglobulin: <B>Cat. No. SAB1402475</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~52.3 kDa using HeLa lysate.

Anti-CIR (AB1) antibody produced in rabbit - AV38523 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: transfected 293T (<B>Cat. No. AV38523</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.25 μg/mL in cell type transfected 293T

CIR1 Antibody - middle region (ARP33736_P050) - ARP33736_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CIR antibody - middle region (ARP33737_P050) - ARP33737_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CIR antibody - C-terminal region (ARP38523_P050) - ARP38523_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CIR-Antibody-C-term - AP1417b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody (C-term)(Cat. #AP1417b). AP1417b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

CIR-Antibody-N-term - AP1417a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CIR Antibody (N-term) (Cat.# AP1417a) western blot analysis in THP-1 cell line,human placenta,rat heart and skeletal muscle lysates (35ug/lane).This demonstrates the CIR antibody detected the CIR protein (arrow).
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