CIR1

Gene Symbol CIR1
Entrez Gene 9541
Alt Symbol CIR
Species Human
Gene Type protein-coding
Description corepressor interacting with RBPJ, 1
Other Description CBF1 interacting corepressor|CBF1-interacting corepressor|corepressor interacting with RBPJ 1|recepin
Swissprots A8K8M4 Q8IWI2 Q86X95 Q4G1B9 Q12804 A6NFI6 Q6PJI4 O95367
Accessions AAY24216 EAX11144 EAX11145 EAX11146 Q86X95 AF098297 AAD05243 AK292389 BAF85078 BC015040 BC021175 AAH21175 BC031018 AAH31018 BC038987 AAH38987 BC046098 AAH46098 BU596189 U03644 AAA17853 NM_199075 NM_004882 NP_004873
Function May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.
Subcellular Location Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Tissue Specificity Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:9874765}.
Top Pathways Notch signaling pathway

Human CBF1 interacting corepressor full length protein - ab160540 from Abcam

Category Protein
Prices $402.00
Sizes 2 µg
Source Wheat germ
Species Human
ab160540 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CBF1 interacting corepressor protein fragment - ab160541 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab160541 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CIR1 - H00009541-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

CIR1 - H00009541-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CIR1 - H00009541-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Recombinant Human Corepressor interacting with RBPJ 1(CIR1) - CSB-YP773051HU CSB-EP773051HU CSB-BP773051HU CSB-MP773051HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CIR-Antibody-C-term-Blocking-Peptide - BP1417b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CIR-Antibody-N-term-Blocking-Peptide - BP1417a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Corepressor interacting with RBPJ 1 (CIR1), Recombinant Protein - MBS1423410 from MyBioSource

Category Protein
Prices $1,230.00, $1,230.00, $1,450.00, $1,450.00, $1,995.00, $1,995.00, $2,460.00, $2,460.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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