| Gene Symbol |
CIR1
|
| Entrez Gene |
9541
|
| Alt Symbol |
CIR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
corepressor interacting with RBPJ, 1
|
| Other Description |
CBF1 interacting corepressor|CBF1-interacting corepressor|corepressor interacting with RBPJ 1|recepin
|
| Swissprots |
A8K8M4 Q8IWI2 Q86X95 Q4G1B9 Q12804 A6NFI6 Q6PJI4 O95367
|
| Accessions |
AAY24216 EAX11144 EAX11145 EAX11146 Q86X95 AF098297 AAD05243 AK292389 BAF85078 BC015040 BC021175 AAH21175 BC031018 AAH31018 BC038987 AAH38987 BC046098 AAH46098 BU596189 U03644 AAA17853 NM_199075 NM_004882 NP_004873
|
| Function |
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.
|
| Subcellular Location |
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
|
| Tissue Specificity |
Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:9874765}.
|
| Top Pathways |
Notch signaling pathway
|