USP5

Gene Symbol USP5
Entrez Gene 8078
Alt Symbol ISOT
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 5 (isopeptidase T)
Other Description deubiquitinating enzyme 5|isopeptidase T|ubiquitin carboxyl-terminal hydrolase 5|ubiquitin isopeptidase T|ubiquitin specific protease 5 (isopeptidase T)|ubiquitin thioesterase 5|ubiquitin thiolesterase 5|ubiquitin-specific protease-5 (ubiquitin isopeptidase T)|ubiquitin-specific-processing protease 5
Swissprots D3DUS7 D3DUS8 Q96J22 P45974
Accessions AAB51314 AAB51315 EAW88724 EAW88725 EAW88726 EAW88727 P45974 AI289395 AK308021 AU099996 BC004889 AAH04889 BC005139 AAH05139 CN276110 DQ893030 ABM83956 DQ896274 ABM87273 U35116 AAA78934 U47927 AAC50465 X91349 CAA62690 XR_931526 XR_931527 NM_001098536 NP_001092006 NM_003481 NP_003472
Function Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.

USP5 (C-11) - sc-390943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
USP5 (C-11): sc-390943. Western blot analysis of USP5 expression in MCF7 (A), A549 (B) and K-562 (C) whole cell lysates.

USP5 (E-14) - sc-79811 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

USP5 (H-120) - sc-366624 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
USP5 (H-120): sc-366624. Western blot analysis of USP5 expression in non-transfected 293T: sc-117752 (A), human USP5 transfected 293T: sc-173732 (B), MCF7 (C), A549 (D) and A-375 (E) whole cell lysates.

Anti-USP5 antibody - ab124327 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-USP5 antibody (ab124327) at 1/500 dilutionLane 1 : MCF7 cell lysateLane 2 : A549 cell lysateLane 3 : K562 cell lysateLane 4 : Human fetal liver lysateLane 5 : Human fetal brain lysate

Anti-USP5 antibody - ab80595 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling USP5 with ab80595 at 1/1000 (1µg/ml). Detection: DAB.

Anti-USP5 antibody - ab84695 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84695, at 1/100 dilution, staining USP5 in formalin-fixed, paraffin-embedded human colon carcinoma by Immunohistochemistry using a Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.

Anti-USP5 antibody - ab38509 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-USP5 antibody (ab38509) + HL-60 cell lysate

Anti-USP5 antibody - ab56372 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56372 USP5 antibody at 1ug/ml.

Anti-USP5 antibody [1A8] - ab118982 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A8
All lanes : Anti-USP5 antibody [1A8] (ab118982) at 1/2000 dilutionLane 1 : HEK293T cells were transfected with the pCMV6-ENTRY control Lane 2 : HEK293T cells were transfected with the pCMV6-ENTRY USP5 cDNALysates/proteins at 5 µg per lane.

Anti-USP5 antibody [EPR10453] - ab155993 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10453
All lanes : Anti-USP5 antibody [EPR10453] (ab155993) at 1/1000 dilutionLane 1 : A549 cell lysateLane 2 : K562 cell lysateLane 3 : A375 cell lysateLane 4 : MCF7 cell lysate Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-USP5 antibody [EPR10454] - ab154170 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10454
All lanes : Anti-USP5 antibody [EPR10454] (ab154170) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : A549 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-USP5 Antibody - LS-C86282 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (aa204-217) - LS-C148075 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GFP in 20 ugs of A) transfected HeLa cells and B) untransfected HeLa cells using LS-C148075 at 0.5 ug/ml.

Anti-USP5 Antibody (aa484-514) - LS-C99537 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-USP5 antibody is used in Western blot to detect USP5 in HL-60 cell lysate.

Anti-USP5 Antibody (C-Terminus, AP) - LS-C284098 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (C-Terminus, APC) - LS-C284100 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (C-Terminus, Biotin) - LS-C284101 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (C-Terminus, FITC) - LS-C284102 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (C-Terminus, Azide-free, HRP) - LS-C284103 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (aa75-125) - LS-C288334 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (C-Terminus, PE) - LS-C284104 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (aa2-223) - LS-C178920 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody - LS-C305916 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-USP5 Antibody (C-Terminus) - LS-C329045 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP5 Antibody (clone 2C8) - LS-C198526 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C8
Detection limit for recombinant GST tagged USP5 is approximately 0.03 ng/ml as a capture antibody.
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